| http://purl.uniprot.org/citations/23172686 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23172686 | http://www.w3.org/2000/01/rdf-schema#comment | "Silent information regulator T1 (SirT1) is linked to longevity and negatively controls NF-κB signaling, a crucial mediator of survival and regulator of both osteoclasts and osteoblasts. Here we show that NF-κB repression by SirT1 in both osteoclasts and osteoblasts is necessary for proper bone remodeling and may contribute to the mechanisms linking aging and bone loss. Osteoclast- or osteoblast-specific SirT1 deletion using the Sirt(flox/flox) mice crossed to lysozyme M-cre and the 2.3 kb col1a1-cre transgenic mice, respectively, resulted in decreased bone mass caused by increased resorption and reduced bone formation. In osteoclasts, lack of SirT1 promoted osteoclastogenesis in vitro and activated NF-κB by increasing acetylation of Lysine 310. Importantly, this increase in osteoclastogenesis was blocked by pharmacological inhibition of NF-κB. In osteoblasts, decreased SirT1 reduced osteoblast differentiation, which could also be rescued by inhibition of NF-κB. In further support of the critical role of NF-κB signaling in bone remodeling, elevated NF-κB activity in IκBα(+/-) mice uncoupled bone resorption and formation, leading to reduced bone mass. These findings support the notion that SirT1 is a genetic determinant of bone mass, acting in a cell-autonomous manner in both osteoblasts and osteoclasts, through control of NF-κB and bone cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/23172686 | http://purl.org/dc/terms/identifier | "doi:10.1002/jbmr.1824"xsd:string |
| http://purl.uniprot.org/citations/23172686 | http://purl.uniprot.org/core/author | "Edwards J.R."xsd:string |
| http://purl.uniprot.org/citations/23172686 | http://purl.uniprot.org/core/author | "Ono K."xsd:string |
| http://purl.uniprot.org/citations/23172686 | http://purl.uniprot.org/core/author | "Moore M.M."xsd:string |
| http://purl.uniprot.org/citations/23172686 | http://purl.uniprot.org/core/author | "Mundy G.R."xsd:string |
| http://purl.uniprot.org/citations/23172686 | http://purl.uniprot.org/core/author | "Elefteriou F."xsd:string |
| http://purl.uniprot.org/citations/23172686 | http://purl.uniprot.org/core/author | "Yull F.E."xsd:string |
| http://purl.uniprot.org/citations/23172686 | http://purl.uniprot.org/core/author | "Fleming N."xsd:string |
| http://purl.uniprot.org/citations/23172686 | http://purl.uniprot.org/core/author | "Connelly L."xsd:string |
| http://purl.uniprot.org/citations/23172686 | http://purl.uniprot.org/core/author | "Perrien D.S."xsd:string |
| http://purl.uniprot.org/citations/23172686 | http://purl.uniprot.org/core/author | "Lwin S.T."xsd:string |
| http://purl.uniprot.org/citations/23172686 | http://purl.uniprot.org/core/author | "Nyman J.S."xsd:string |
| http://purl.uniprot.org/citations/23172686 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23172686 | http://purl.uniprot.org/core/name | "J Bone Miner Res"xsd:string |
| http://purl.uniprot.org/citations/23172686 | http://purl.uniprot.org/core/pages | "960-969"xsd:string |
| http://purl.uniprot.org/citations/23172686 | http://purl.uniprot.org/core/title | "Silent information regulator (Sir)T1 inhibits NF-kappaB signaling to maintain normal skeletal remodeling."xsd:string |
| http://purl.uniprot.org/citations/23172686 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/23172686 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23172686 |
| http://purl.uniprot.org/citations/23172686 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23172686 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGK6-mappedCitation-23172686 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23172686 |
| http://purl.uniprot.org/uniprot/#_A0A077S2U6-mappedCitation-23172686 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23172686 |
| http://purl.uniprot.org/uniprot/#_A7MCT8-mappedCitation-23172686 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23172686 |
| http://purl.uniprot.org/uniprot/#_F6YAQ3-mappedCitation-23172686 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23172686 |