| http://purl.uniprot.org/citations/23175841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23175841 | http://www.w3.org/2000/01/rdf-schema#comment | "In the postnatal forebrain, the subventricular zone (SVZ) contains a pool of undifferentiated cells, which proliferate and migrate along the rostral migratory stream (RMS) to the olfactory bulb and differentiate into granule cells and periglomerular cells. Plexin-B2 is a semaphorin receptor previously known to act on neuronal proliferation in the embryonic brain and neuronal migration in the cerebellum. We show here that, in the postnatal and adult CNS, Plexin-B2 is expressed in the subventricular zone lining the telencephalic ventricles and in the rostral migratory stream. We analyzed Plxnb2(-/-) mice and found that there is a marked reduction in the proliferation of SVZ cells in the mutant. Plexin-B2 expression is downregulated in the olfactory bulb as interneurons initiate radial migration. BrdU labeling and GFP electroporation into postnatal SVZ, in addition to time-lapse videomicroscopy, revealed that neuroblasts deficient for Plexin-B2 migrate faster than control ones and leave the RMS more rapidly. Overall, these results show that Plexin-B2 plays a role in postnatal neurogenesis and in the migration of SVZ-derived neuroblasts."xsd:string |
| http://purl.uniprot.org/citations/23175841 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.0344-12.2012"xsd:string |
| http://purl.uniprot.org/citations/23175841 | http://purl.uniprot.org/core/author | "Boutin C."xsd:string |
| http://purl.uniprot.org/citations/23175841 | http://purl.uniprot.org/core/author | "Cremer H."xsd:string |
| http://purl.uniprot.org/citations/23175841 | http://purl.uniprot.org/core/author | "Saha B."xsd:string |
| http://purl.uniprot.org/citations/23175841 | http://purl.uniprot.org/core/author | "Chedotal A."xsd:string |
| http://purl.uniprot.org/citations/23175841 | http://purl.uniprot.org/core/author | "Ypsilanti A.R."xsd:string |
| http://purl.uniprot.org/citations/23175841 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23175841 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/23175841 | http://purl.uniprot.org/core/pages | "16892-16905"xsd:string |
| http://purl.uniprot.org/citations/23175841 | http://purl.uniprot.org/core/title | "Plexin-B2 regulates the proliferation and migration of neuroblasts in the postnatal and adult subventricular zone."xsd:string |
| http://purl.uniprot.org/citations/23175841 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/23175841 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23175841 |
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