| http://purl.uniprot.org/citations/23178297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23178297 | http://www.w3.org/2000/01/rdf-schema#comment | "Phosphatase of regenerating liver (PRL-3) promotes cancer metastasis through enhanced cell motility and invasiveness, however its role in tumorigenesis remains unclear. Herein, we reported that PRL-3 interacts with telomere-related protein RAP1. PRL-3 promotes the cytosolic localization of RAP1, which is counteracted by silencing of PRL-3. Immunohistochemical staining of colon cancer tissue array (n=170) revealed that high level of PRL-3 associates with cytosolic localization of RAP1 (p=0.01). Microarray analysis showed that PRL-3 regulates expression of diverse genes and enhances phosphorylation of p65 subunit of NF-κB in a RAP1-dependent manner. Furthermore, PRL-3 transcriptionally activates RAP1 expression, which is counteracted by ablating p65. Therefore, our results demonstrate PRL-3 as a novel regulator of NF-κB signaling pathway through RAP1."xsd:string |
| http://purl.uniprot.org/citations/23178297 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2012.11.036"xsd:string |
| http://purl.uniprot.org/citations/23178297 | http://purl.uniprot.org/core/author | "Han Y."xsd:string |
| http://purl.uniprot.org/citations/23178297 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/23178297 | http://purl.uniprot.org/core/author | "Dong B."xsd:string |
| http://purl.uniprot.org/citations/23178297 | http://purl.uniprot.org/core/author | "Peng L."xsd:string |
| http://purl.uniprot.org/citations/23178297 | http://purl.uniprot.org/core/author | "Qu L."xsd:string |
| http://purl.uniprot.org/citations/23178297 | http://purl.uniprot.org/core/author | "Song Q."xsd:string |
| http://purl.uniprot.org/citations/23178297 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/23178297 | http://purl.uniprot.org/core/author | "Meng L."xsd:string |
| http://purl.uniprot.org/citations/23178297 | http://purl.uniprot.org/core/author | "Xing X."xsd:string |
| http://purl.uniprot.org/citations/23178297 | http://purl.uniprot.org/core/author | "Shou C."xsd:string |
| http://purl.uniprot.org/citations/23178297 | http://purl.uniprot.org/core/author | "Lian S."xsd:string |
| http://purl.uniprot.org/citations/23178297 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23178297 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/23178297 | http://purl.uniprot.org/core/pages | "196-201"xsd:string |
| http://purl.uniprot.org/citations/23178297 | http://purl.uniprot.org/core/title | "PRL-3 activates NF-kappaB signaling pathway by interacting with RAP1."xsd:string |
| http://purl.uniprot.org/citations/23178297 | http://purl.uniprot.org/core/volume | "430"xsd:string |
| http://purl.uniprot.org/citations/23178297 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23178297 |
| http://purl.uniprot.org/citations/23178297 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23178297 |
| http://purl.uniprot.org/uniprot/P07437#attribution-059C4A8A0CE4FB7A64431D47CF7E5CE1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23178297 |
| http://purl.uniprot.org/uniprot/Q04206#attribution-93BDA7D720EAA09BABC29F8897E46D91 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23178297 |
| http://purl.uniprot.org/uniprot/Q9NYB0#attribution-059C4A8A0CE4FB7A64431D47CF7E5CE1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23178297 |
| http://purl.uniprot.org/uniprot/Q9NYB0#attribution-93BDA7D720EAA09BABC29F8897E46D91 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23178297 |