| http://purl.uniprot.org/citations/23178882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23178882 | http://www.w3.org/2000/01/rdf-schema#comment | "Basal cell carcinoma, the most frequent human skin cancer, arises from activating hedgehog (HH) pathway mutations; however, little is known about the temporal changes that occur in tumour-initiating cells from the first oncogenic hit to the development of invasive cancer. Using an inducible mouse model enabling the expression of a constitutively active Smoothened mutant (SmoM2) in the adult epidermis, we carried out transcriptional profiling of SmoM2-expressing cells at different times during cancer initiation. We found that tumour-initiating cells are massively reprogrammed into a fate resembling that of embryonic hair follicle progenitors (EHFPs). Wnt/ β-catenin signalling was very rapidly activated following SmoM2 expression in adult epidermis and coincided with the expression of EHFP markers. Deletion of β-catenin in adult SmoM2-expressing cells prevents EHFP reprogramming and tumour initiation. Finally, human basal cell carcinomas also express genes of the Wnt signalling and EHFP signatures."xsd:string |
| http://purl.uniprot.org/citations/23178882 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb2628"xsd:string |
| http://purl.uniprot.org/citations/23178882 | http://purl.uniprot.org/core/author | "del Marmol V."xsd:string |
| http://purl.uniprot.org/citations/23178882 | http://purl.uniprot.org/core/author | "Blanpain C."xsd:string |
| http://purl.uniprot.org/citations/23178882 | http://purl.uniprot.org/core/author | "Aerts S."xsd:string |
| http://purl.uniprot.org/citations/23178882 | http://purl.uniprot.org/core/author | "Rorive S."xsd:string |
| http://purl.uniprot.org/citations/23178882 | http://purl.uniprot.org/core/author | "Salmon I."xsd:string |
| http://purl.uniprot.org/citations/23178882 | http://purl.uniprot.org/core/author | "Dekoninck S."xsd:string |
| http://purl.uniprot.org/citations/23178882 | http://purl.uniprot.org/core/author | "Sukumaran V."xsd:string |
| http://purl.uniprot.org/citations/23178882 | http://purl.uniprot.org/core/author | "Lapouge G."xsd:string |
| http://purl.uniprot.org/citations/23178882 | http://purl.uniprot.org/core/author | "Bouvree K."xsd:string |
| http://purl.uniprot.org/citations/23178882 | http://purl.uniprot.org/core/author | "Youssef K.K."xsd:string |
| http://purl.uniprot.org/citations/23178882 | http://purl.uniprot.org/core/author | "Brohee S."xsd:string |
| http://purl.uniprot.org/citations/23178882 | http://purl.uniprot.org/core/author | "Pucci D."xsd:string |
| http://purl.uniprot.org/citations/23178882 | http://purl.uniprot.org/core/author | "Van de Sande B."xsd:string |
| http://purl.uniprot.org/citations/23178882 | http://purl.uniprot.org/core/author | "Appelstein O."xsd:string |
| http://purl.uniprot.org/citations/23178882 | http://purl.uniprot.org/core/author | "Berthe J.V."xsd:string |
| http://purl.uniprot.org/citations/23178882 | http://purl.uniprot.org/core/author | "Larsimont J.C."xsd:string |
| http://purl.uniprot.org/citations/23178882 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23178882 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/23178882 | http://purl.uniprot.org/core/pages | "1282-1294"xsd:string |
| http://purl.uniprot.org/citations/23178882 | http://purl.uniprot.org/core/title | "Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation."xsd:string |
| http://purl.uniprot.org/citations/23178882 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/23178882 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23178882 |