| http://purl.uniprot.org/citations/23184931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23184931 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-13 is a potent stimulator of alternative monocyte/macrophage activation. During alternative activation, the expression of several proteins is induced including 15-lipoxygenase (15-LO), a lipid-peroxidating enzyme and the scavenger receptor CD36. We previously reported that α(M)β(2) integrin activation or clustering suppresses the expression of both 15-LO and CD36. In this study we focused on exploring the molecular mechanisms that down-regulate CD36 expression and CD36-mediated foam cell formation in IL-13-stimulated monocytes/macrophages after α(M)β(2) activation. Our studies reveal that α(M)β(2) integrin activation inhibits the IL-13 activation of several critical pathways that are required for macrophage alternative activation; namely, blocking Jak2 and Tyk2 phosphorylation, which bind to the cytoplasmic tails of the IL-4Rα/IL-13Rα1 complex. This leads to the inhibition of tyrosine phosphorylation of Stats (Stat1, Stat3, and Stat6) and prevents the formation of a signaling complex (containing p38MAPK, PKCδ, and Stat3) that are critical for the expression of both 15-LO and CD36. Jak2-mediated Hck activation is also inhibited, thereby preventing Stats serine phosphorylation, which is essential for downstream Stat-dependent gene transcription. Moreover, inhibition of Jak2, Tyk2, or their downstream target 15-LO with antisense oligonucleotides profoundly inhibits IL-13-induced CD36 expression and CD36-dependent foam cell formation, whereas13(S) Hydroperoxyoctadecadienoic acid (HPODE), a 15-LO product and peroxisome proliferator-activated receptor-γ ligand, completely restores CD36 expression in monocytes treated with 15-LO antisense. α(M)β(2) integrin activation controls CD36 expression and foam cell formation in alternatively activated monocyte/macrophages by blocking Tyk2/Jak2 phosphorylation via a 15-LO-dependent pathway. The discovery of this mechanism helps our understanding of the potential role of alternatively activated macrophages in atherogenesis and highlights the impact of integrin α(M)β(2) on this process."xsd:string |
| http://purl.uniprot.org/citations/23184931 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m112.381343"xsd:string |
| http://purl.uniprot.org/citations/23184931 | http://purl.uniprot.org/core/author | "Bhattacharjee A."xsd:string |
| http://purl.uniprot.org/citations/23184931 | http://purl.uniprot.org/core/author | "Yakubenko V.P."xsd:string |
| http://purl.uniprot.org/citations/23184931 | http://purl.uniprot.org/core/author | "Hsi L.C."xsd:string |
| http://purl.uniprot.org/citations/23184931 | http://purl.uniprot.org/core/author | "Cathcart M.K."xsd:string |
| http://purl.uniprot.org/citations/23184931 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23184931 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/23184931 | http://purl.uniprot.org/core/pages | "2778-2788"xsd:string |
| http://purl.uniprot.org/citations/23184931 | http://purl.uniprot.org/core/title | "From macrophage interleukin-13 receptor to foam cell formation: mechanisms for alphaMbeta2 integrin interference."xsd:string |
| http://purl.uniprot.org/citations/23184931 | http://purl.uniprot.org/core/volume | "288"xsd:string |
| http://purl.uniprot.org/citations/23184931 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23184931 |
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