| http://purl.uniprot.org/citations/23185005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23185005 | http://www.w3.org/2000/01/rdf-schema#comment | "A disintegrin-like metalloproteinase with thrombospondin motifs-16 (Adamts16) is an important candidate gene for hypertension. The goal of the present study was to further assess the candidacy of Adamts16 by targeted disruption of this gene in a rat genetic model of hypertension. A rat model was generated by manipulating the genome of the Dahl Salt-sensitive (S) rat using zinc-finger nucleases, wherein the mutant rat had a 17 bp deletion in the first exon of Adamts16, introducing a stop codon in the transcript. Systolic blood pressure (BP) of the homozygous Adamts16(mutant) rats was lower by 36 mmHg compared with the BP of the S rats. The Adamts16(mutant) rats exhibited significantly lower aortic pulse wave velocity and vascular media thickness compared with S rats. Scanning electron and fluorescence microscopic studies indicated that the mechanosensory cilia of vascular endothelial cells from the Adamts16(mutant) rats were longer than that of the S rats. Furthermore, Adamts16(mutant) rats showed splitting and thickening of glomerular capillaries and had a longer survival rate, compared with the S rats. Taken together, these physiological observations functionally link Adamts16 to BP regulation and suggest the vasculature as the potential site of action of Adamts16 to lower BP."xsd:string |
| http://purl.uniprot.org/citations/23185005 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1211290109"xsd:string |
| http://purl.uniprot.org/citations/23185005 | http://purl.uniprot.org/core/author | "Joe B."xsd:string |
| http://purl.uniprot.org/citations/23185005 | http://purl.uniprot.org/core/author | "Saunders T.L."xsd:string |
| http://purl.uniprot.org/citations/23185005 | http://purl.uniprot.org/core/author | "Nauli S.M."xsd:string |
| http://purl.uniprot.org/citations/23185005 | http://purl.uniprot.org/core/author | "Gopalakrishnan K."xsd:string |
| http://purl.uniprot.org/citations/23185005 | http://purl.uniprot.org/core/author | "Morgan E.E."xsd:string |
| http://purl.uniprot.org/citations/23185005 | http://purl.uniprot.org/core/author | "Kumarasamy S."xsd:string |
| http://purl.uniprot.org/citations/23185005 | http://purl.uniprot.org/core/author | "Abdul-Majeed S."xsd:string |
| http://purl.uniprot.org/citations/23185005 | http://purl.uniprot.org/core/author | "Filipiak W.E."xsd:string |
| http://purl.uniprot.org/citations/23185005 | http://purl.uniprot.org/core/author | "Gohara A.F."xsd:string |
| http://purl.uniprot.org/citations/23185005 | http://purl.uniprot.org/core/author | "Kalinoski A.L."xsd:string |
| http://purl.uniprot.org/citations/23185005 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23185005 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/23185005 | http://purl.uniprot.org/core/pages | "20555-20559"xsd:string |
| http://purl.uniprot.org/citations/23185005 | http://purl.uniprot.org/core/title | "Targeted disruption of Adamts16 gene in a rat genetic model of hypertension."xsd:string |
| http://purl.uniprot.org/citations/23185005 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/23185005 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23185005 |
| http://purl.uniprot.org/citations/23185005 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23185005 |
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| http://purl.uniprot.org/uniprot/#_A6JUZ7-mappedCitation-23185005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23185005 |
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