| http://purl.uniprot.org/citations/23195496 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23195496 | http://www.w3.org/2000/01/rdf-schema#comment | "Autophagy is an evolutionarily conserved pathway responsible for delivery of cytoplasmic material into the lysosomal degradation pathway to enable vesicular exocytosis. Interleukin (IL)-2 is produced by T-cells and its activity is important for immunoregulation. Fibroblasts are an immune competent cell type, playing a critical role in wound healing, chronic inflammation, and tumor development. Although autophagy plays an important role in each of these processes, whether it regulates IL-2 activity in fibroblasts is unknown. Here, we show that autophagy is required for IL-2-induced cell growth in fibroblasts. IL-2 significantly induced autophagy in mouse embryonic fibroblasts (MEFs) and primary lung fibroblasts. Autophagy inhibitors (e.g., 3-methylamphetamine and bafilomycin A1) or knockdown of ATG5 and beclin 1 blocked clinical grade IL-2-induced autophagy. Moreover, IL-2 induced HMGB1 cytoplasmic translocation in MEFs and promoted interaction between HMGB1 and beclin1, which is required for autophagy induction. Pharmacological and genetic inhibition of autophagy inhibited IL-2-induced cell proliferation and enhanced IL-2-induced apoptosis. These findings suggest that autophagy is an important pro-survival regulator for IL-2-induced cell growth in fibroblasts."xsd:string |
| http://purl.uniprot.org/citations/23195496 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2012.11.012"xsd:string |
| http://purl.uniprot.org/citations/23195496 | http://purl.uniprot.org/core/author | "Tang D."xsd:string |
| http://purl.uniprot.org/citations/23195496 | http://purl.uniprot.org/core/author | "Kang R."xsd:string |
| http://purl.uniprot.org/citations/23195496 | http://purl.uniprot.org/core/author | "Lotze M.T."xsd:string |
| http://purl.uniprot.org/citations/23195496 | http://purl.uniprot.org/core/author | "Zeh Iii H.J."xsd:string |
| http://purl.uniprot.org/citations/23195496 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23195496 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/23195496 | http://purl.uniprot.org/core/pages | "556-565"xsd:string |
| http://purl.uniprot.org/citations/23195496 | http://purl.uniprot.org/core/title | "Autophagy is required for IL-2-mediated fibroblast growth."xsd:string |
| http://purl.uniprot.org/citations/23195496 | http://purl.uniprot.org/core/volume | "319"xsd:string |
| http://purl.uniprot.org/citations/23195496 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23195496 |
| http://purl.uniprot.org/citations/23195496 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23195496 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUD8-mappedCitation-23195496 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23195496 |
| http://purl.uniprot.org/uniprot/#_E9QAM0-mappedCitation-23195496 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23195496 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUZ4-mappedCitation-23195496 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23195496 |
| http://purl.uniprot.org/uniprot/#_D3YVC6-mappedCitation-23195496 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23195496 |
| http://purl.uniprot.org/uniprot/#_D3YZ18-mappedCitation-23195496 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23195496 |
| http://purl.uniprot.org/uniprot/#_A0A385JBX3-mappedCitation-23195496 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23195496 |
| http://purl.uniprot.org/uniprot/#_F7C090-mappedCitation-23195496 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23195496 |
| http://purl.uniprot.org/uniprot/#_F7CVL9-mappedCitation-23195496 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23195496 |
| http://purl.uniprot.org/uniprot/#_E9PX06-mappedCitation-23195496 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23195496 |
| http://purl.uniprot.org/uniprot/#_O88597-mappedCitation-23195496 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23195496 |
| http://purl.uniprot.org/uniprot/#_F7DB15-mappedCitation-23195496 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23195496 |