| http://purl.uniprot.org/citations/23195957 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23195957 | http://www.w3.org/2000/01/rdf-schema#comment | "Glioblastomas are very difficult tumors to treat because they are highly invasive and disseminate within the normal brain, resulting in newly growing tumors. We have identified netrin-1 as a molecule that promotes glioblastoma invasiveness. As evidence, netrin-1 stimulates glioblastoma cell invasion directly through Matrigel-coated transwells, promotes tumor cell sprouting and enhances metastasis to lymph nodes in vivo. Furthermore, netrin-1 regulates angiogenesis as shown in specific angiogenesis assays such as enhanced capillary endothelial cells (EC) sprouting and by increased EC infiltration into Matrigel plugs in vivo, as does VEGF-A. This netrin-1 signaling pathway in glioblastoma cells includes activation of RhoA and cyclic AMP response element-binding protein (CREB). A novel finding is that netrin-1-induced glioblastoma invasiveness and angiogenesis are mediated by activated cathepsin B (CatB), a cysteine protease that translocates to the cell surface as an active enzyme and co-localizes with cell surface annexin A2 (ANXA2). The specific CatB inhibitor CA-074Me inhibits netrin-1-induced cell invasion, sprouting, and Matrigel plug angiogenesis. Silencing of CREB suppresses netrin-1-induced glioblastoma cell invasion, sprouting, and CatB expression. It is concluded that netrin-1 plays an important dual role in glioblastoma progression by promoting both glioblastoma cell invasiveness and angiogenesis in a RhoA-, CREB-, and CatB-dependent manner. Targeting netrin-1 pathways may be a promising strategy for brain cancer therapy."xsd:string |
| http://purl.uniprot.org/citations/23195957 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m112.397398"xsd:string |
| http://purl.uniprot.org/citations/23195957 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/23195957 | http://purl.uniprot.org/core/author | "Shimizu A."xsd:string |
| http://purl.uniprot.org/citations/23195957 | http://purl.uniprot.org/core/author | "Nakayama H."xsd:string |
| http://purl.uniprot.org/citations/23195957 | http://purl.uniprot.org/core/author | "Italiano J.E. Jr."xsd:string |
| http://purl.uniprot.org/citations/23195957 | http://purl.uniprot.org/core/author | "Akino T."xsd:string |
| http://purl.uniprot.org/citations/23195957 | http://purl.uniprot.org/core/author | "Konig C."xsd:string |
| http://purl.uniprot.org/citations/23195957 | http://purl.uniprot.org/core/author | "Mammoto A."xsd:string |
| http://purl.uniprot.org/citations/23195957 | http://purl.uniprot.org/core/author | "Klagsbrun M."xsd:string |
| http://purl.uniprot.org/citations/23195957 | http://purl.uniprot.org/core/author | "Bielenberg D.R."xsd:string |
| http://purl.uniprot.org/citations/23195957 | http://purl.uniprot.org/core/author | "Sandlund J."xsd:string |
| http://purl.uniprot.org/citations/23195957 | http://purl.uniprot.org/core/author | "Coma S."xsd:string |
| http://purl.uniprot.org/citations/23195957 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23195957 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/23195957 | http://purl.uniprot.org/core/pages | "2210-2222"xsd:string |
| http://purl.uniprot.org/citations/23195957 | http://purl.uniprot.org/core/title | "Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein."xsd:string |
| http://purl.uniprot.org/citations/23195957 | http://purl.uniprot.org/core/volume | "288"xsd:string |
| http://purl.uniprot.org/citations/23195957 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23195957 |
| http://purl.uniprot.org/citations/23195957 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23195957 |
| http://purl.uniprot.org/uniprot/#_A0A024R324-mappedCitation-23195957 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23195957 |
| http://purl.uniprot.org/uniprot/#_A0A024R374-mappedCitation-23195957 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23195957 |
| http://purl.uniprot.org/uniprot/#_A8K2H4-mappedCitation-23195957 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23195957 |
| http://purl.uniprot.org/uniprot/#_P61586-mappedCitation-23195957 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23195957 |