| http://purl.uniprot.org/citations/23197718 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23197718 | http://www.w3.org/2000/01/rdf-schema#comment | "Serine-arginine protein kinases 2 (SRPK2) is a cell cycle-regulated kinase that phosphorylates serine/arginine domain-containing proteins and mediates pre-mRNA splicing with unclear function in neurons. Here, we show that SRPK2 phosphorylates tau on S214, suppresses tau-dependent microtubule polymerization, and inhibits axonal elongation in neurons. Depletion of SRPK2 in dentate gyrus inhibits tau phosphorylation in APP/PS1 mouse and alleviates the impaired cognitive behaviors. The defective LTP in APP/PS1 mice is also improved after SRPK2 depletion. Moreover, active SRPK2 is increased in the cortex of APP/PS1 mice and the pathological structures of human Alzheimer's disease (AD) brain. Therefore, our study suggests SRPK2 may contribute to the formation of hyperphosphorylated tau and the pathogenesis of AD."xsd:string |
| http://purl.uniprot.org/citations/23197718 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.3300-12.2012"xsd:string |
| http://purl.uniprot.org/citations/23197718 | http://purl.uniprot.org/core/author | "Hong Y."xsd:string |
| http://purl.uniprot.org/citations/23197718 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/23197718 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/23197718 | http://purl.uniprot.org/core/author | "Ye K."xsd:string |
| http://purl.uniprot.org/citations/23197718 | http://purl.uniprot.org/core/author | "Jin P."xsd:string |
| http://purl.uniprot.org/citations/23197718 | http://purl.uniprot.org/core/author | "Lee H.G."xsd:string |
| http://purl.uniprot.org/citations/23197718 | http://purl.uniprot.org/core/author | "Song M."xsd:string |
| http://purl.uniprot.org/citations/23197718 | http://purl.uniprot.org/core/author | "Lee H.P."xsd:string |
| http://purl.uniprot.org/citations/23197718 | http://purl.uniprot.org/core/author | "Kwon I.S."xsd:string |
| http://purl.uniprot.org/citations/23197718 | http://purl.uniprot.org/core/author | "Yu S.P."xsd:string |
| http://purl.uniprot.org/citations/23197718 | http://purl.uniprot.org/core/author | "Chan C.B."xsd:string |
| http://purl.uniprot.org/citations/23197718 | http://purl.uniprot.org/core/author | "Sompol P."xsd:string |
| http://purl.uniprot.org/citations/23197718 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23197718 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/23197718 | http://purl.uniprot.org/core/pages | "17262-17272"xsd:string |
| http://purl.uniprot.org/citations/23197718 | http://purl.uniprot.org/core/title | "SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/23197718 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/23197718 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23197718 |
| http://purl.uniprot.org/citations/23197718 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23197718 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JDT6-mappedCitation-23197718 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23197718 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JDY2-mappedCitation-23197718 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23197718 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JG74-mappedCitation-23197718 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23197718 |