| http://purl.uniprot.org/citations/23201126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23201126 | http://www.w3.org/2000/01/rdf-schema#comment | "The production of pigment by melanocytes tans the skin and protects against skin cancers. UV-exposed keratinocytes secrete α-MSH, which then activates melanin formation in melanocytes by inducing the microphthalmia-associated transcription factor (MITF). We show that PPAR-γ coactivator (PGC)-1α and PGC-1β are critical components of this melanogenic system in melanocytes. α-MSH signaling strongly induces PGC-1α expression and stabilizes both PGC-1α and PGC-1β proteins. The PGC-1s in turn activate the MITF promoter, and their expression correlates strongly with that of MITF in human melanoma cell lines and biopsy specimens. Inhibition of PGC-1α and PGC-1β blocks the α-MSH-mediated induction of MITF and melanogenic genes. Conversely, overexpression of PGC-1α induces pigment formation in cell culture and transgenic animals. Finally, polymorphism studies reveal expression quantitative trait loci in the PGC-1β gene that correlate with tanning ability and protection from melanoma in humans. These data identify PGC-1 coactivators as regulators of human tanning."xsd:string |
| http://purl.uniprot.org/citations/23201126 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2012.10.027"xsd:string |
| http://purl.uniprot.org/citations/23201126 | http://purl.uniprot.org/core/author | "Han J."xsd:string |
| http://purl.uniprot.org/citations/23201126 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/23201126 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/23201126 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/23201126 | http://purl.uniprot.org/core/author | "Cui R."xsd:string |
| http://purl.uniprot.org/citations/23201126 | http://purl.uniprot.org/core/author | "Wei Q."xsd:string |
| http://purl.uniprot.org/citations/23201126 | http://purl.uniprot.org/core/author | "Qureshi A.A."xsd:string |
| http://purl.uniprot.org/citations/23201126 | http://purl.uniprot.org/core/author | "Lee J.E."xsd:string |
| http://purl.uniprot.org/citations/23201126 | http://purl.uniprot.org/core/author | "Amos C.I."xsd:string |
| http://purl.uniprot.org/citations/23201126 | http://purl.uniprot.org/core/author | "Arany Z."xsd:string |
| http://purl.uniprot.org/citations/23201126 | http://purl.uniprot.org/core/author | "Kupper T.S."xsd:string |
| http://purl.uniprot.org/citations/23201126 | http://purl.uniprot.org/core/author | "Jiang A."xsd:string |
| http://purl.uniprot.org/citations/23201126 | http://purl.uniprot.org/core/author | "Fisher D.E."xsd:string |
| http://purl.uniprot.org/citations/23201126 | http://purl.uniprot.org/core/author | "Haq R."xsd:string |
| http://purl.uniprot.org/citations/23201126 | http://purl.uniprot.org/core/author | "Rowe G.C."xsd:string |
| http://purl.uniprot.org/citations/23201126 | http://purl.uniprot.org/core/author | "Shoag J."xsd:string |
| http://purl.uniprot.org/citations/23201126 | http://purl.uniprot.org/core/author | "Koulisis N."xsd:string |
| http://purl.uniprot.org/citations/23201126 | http://purl.uniprot.org/core/author | "Farrel C."xsd:string |
| http://purl.uniprot.org/citations/23201126 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23201126 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/23201126 | http://purl.uniprot.org/core/pages | "145-157"xsd:string |
| http://purl.uniprot.org/citations/23201126 | http://purl.uniprot.org/core/title | "PGC-1 coactivators regulate MITF and the tanning response."xsd:string |