| http://purl.uniprot.org/citations/23202293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23202293 | http://www.w3.org/2000/01/rdf-schema#comment | "β-arrestins are associated with numerous aspects of G protein-coupled receptor (GPCR) signaling and regulation and accordingly influence diverse physiological and pathophysiological processes. Here we report that β-arrestin 2 expression is elevated in two independent cohorts of individuals with Alzheimer's disease. Overexpression of β-arrestin 2 leads to an increase in amyloid-β (Aβ) peptide generation, whereas genetic silencing of Arrb2 (encoding β-arrestin 2) reduces generation of Aβ in cell cultures and in Arrb2(-/-) mice. Moreover, in a transgenic mouse model of Alzheimer's disease, genetic deletion of Arrb2 leads to a reduction in the production of Aβ(40) and Aβ(42). Two GPCRs implicated previously in Alzheimer's disease (GPR3 and the β(2)-adrenergic receptor) mediate their effects on Aβ generation through interaction with β-arrestin 2. β-arrestin 2 physically associates with the Aph-1a subunit of the γ-secretase complex and redistributes the complex toward detergent-resistant membranes, increasing the catalytic activity of the complex. Collectively, these studies identify β-arrestin 2 as a new therapeutic target for reducing amyloid pathology and GPCR dysfunction in Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/23202293 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm.3023"xsd:string |
| http://purl.uniprot.org/citations/23202293 | http://purl.uniprot.org/core/author | "Huang Y."xsd:string |
| http://purl.uniprot.org/citations/23202293 | http://purl.uniprot.org/core/author | "De Strooper B."xsd:string |
| http://purl.uniprot.org/citations/23202293 | http://purl.uniprot.org/core/author | "Munck S."xsd:string |
| http://purl.uniprot.org/citations/23202293 | http://purl.uniprot.org/core/author | "Thathiah A."xsd:string |
| http://purl.uniprot.org/citations/23202293 | http://purl.uniprot.org/core/author | "Horre K."xsd:string |
| http://purl.uniprot.org/citations/23202293 | http://purl.uniprot.org/core/author | "Snellinx A."xsd:string |
| http://purl.uniprot.org/citations/23202293 | http://purl.uniprot.org/core/author | "Ciesielska M."xsd:string |
| http://purl.uniprot.org/citations/23202293 | http://purl.uniprot.org/core/author | "De Kloe G."xsd:string |
| http://purl.uniprot.org/citations/23202293 | http://purl.uniprot.org/core/author | "Vandewyer E."xsd:string |
| http://purl.uniprot.org/citations/23202293 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23202293 | http://purl.uniprot.org/core/name | "Nat Med"xsd:string |
| http://purl.uniprot.org/citations/23202293 | http://purl.uniprot.org/core/pages | "43-49"xsd:string |
| http://purl.uniprot.org/citations/23202293 | http://purl.uniprot.org/core/title | "beta-arrestin 2 regulates Abeta generation and gamma-secretase activity in Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/23202293 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/23202293 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23202293 |
| http://purl.uniprot.org/citations/23202293 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23202293 |
| http://purl.uniprot.org/uniprot/#_A0A158SIT9-mappedCitation-23202293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23202293 |
| http://purl.uniprot.org/uniprot/#_J3QN53-mappedCitation-23202293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23202293 |
| http://purl.uniprot.org/uniprot/#_G3UZ54-mappedCitation-23202293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23202293 |
| http://purl.uniprot.org/uniprot/#_J3QNV6-mappedCitation-23202293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23202293 |
| http://purl.uniprot.org/uniprot/#_J3JS97-mappedCitation-23202293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23202293 |
| http://purl.uniprot.org/uniprot/#_Q3TRC8-mappedCitation-23202293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23202293 |