| http://purl.uniprot.org/citations/23208550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23208550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23208550 | http://www.w3.org/2000/01/rdf-schema#comment | "β-arrestin 1 and 2 (also known as arrestin 2 and 3) are homologous adaptor proteins that regulate seven-transmembrane receptor trafficking and signalling. Other proteins with predicted 'arrestin-like' structural domains but lacking sequence homology have been indicated to function like β-arrestin in receptor regulation. We demonstrate that β-arrestin2 is the primary adaptor that rapidly binds agonist-activated β(2) adrenergic receptors (β(2)ARs) and promotes clathrin-dependent internalization, E3 ligase Nedd4 recruitment and ubiquitin-dependent lysosomal degradation of the receptor. The arrestin-domain-containing (ARRDC) proteins 2, 3 and 4 are secondary adaptors recruited to internalized β(2)AR-Nedd4 complexes on endosomes and do not affect the adaptor roles of β-arrestin2. Rather, the role of ARRDC proteins is to traffic Nedd4-β(2)AR complexes to a subpopulation of early endosomes."xsd:string |
| http://purl.uniprot.org/citations/23208550 | http://purl.org/dc/terms/identifier | "doi:10.1038/embor.2012.187"xsd:string |
| http://purl.uniprot.org/citations/23208550 | http://purl.org/dc/terms/identifier | "doi:10.1038/embor.2012.187"xsd:string |
| http://purl.uniprot.org/citations/23208550 | http://purl.uniprot.org/core/author | "Han S.O."xsd:string |
| http://purl.uniprot.org/citations/23208550 | http://purl.uniprot.org/core/author | "Han S.O."xsd:string |
| http://purl.uniprot.org/citations/23208550 | http://purl.uniprot.org/core/author | "Shenoy S.K."xsd:string |
| http://purl.uniprot.org/citations/23208550 | http://purl.uniprot.org/core/author | "Shenoy S.K."xsd:string |
| http://purl.uniprot.org/citations/23208550 | http://purl.uniprot.org/core/author | "Kommaddi R.P."xsd:string |
| http://purl.uniprot.org/citations/23208550 | http://purl.uniprot.org/core/author | "Kommaddi R.P."xsd:string |
| http://purl.uniprot.org/citations/23208550 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23208550 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23208550 | http://purl.uniprot.org/core/name | "EMBO Rep."xsd:string |
| http://purl.uniprot.org/citations/23208550 | http://purl.uniprot.org/core/name | "EMBO Rep."xsd:string |
| http://purl.uniprot.org/citations/23208550 | http://purl.uniprot.org/core/pages | "164-171"xsd:string |
| http://purl.uniprot.org/citations/23208550 | http://purl.uniprot.org/core/pages | "164-171"xsd:string |
| http://purl.uniprot.org/citations/23208550 | http://purl.uniprot.org/core/title | "Distinct roles for beta-arrestin2 and arrestin-domain-containing proteins in beta2 adrenergic receptor trafficking."xsd:string |
| http://purl.uniprot.org/citations/23208550 | http://purl.uniprot.org/core/title | "Distinct roles for beta-arrestin2 and arrestin-domain-containing proteins in beta2 adrenergic receptor trafficking."xsd:string |
| http://purl.uniprot.org/citations/23208550 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/23208550 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/23208550 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23208550 |
| http://purl.uniprot.org/citations/23208550 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23208550 |
| http://purl.uniprot.org/citations/23208550 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23208550 |
| http://purl.uniprot.org/citations/23208550 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23208550 |