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http://purl.uniprot.org/citations/23213272http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23213272http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

Primary and recurrent infections of the cornea by herpes simplex virus 1 (HSV-1) are important causes of eye disease. Three unrelated classes of glycoprotein D receptors for HSV-1 entry into cells have been identified. This study was undertaken to uncover the relative significance of nectin-1 as an entry receptor in corneal infection and HSV-1 spread to the trigeminal ganglia (TG), a site important for HSV-1 latency and recurrent corneal infection.

Methods

To assess the significance of nectin-1, a member of the immunoglobulin superfamily, in primary HSV-1 infection and spread to the TG, we used a murine model of corneal infection and a HSV-1 mutant, KOS(Rid1), which can only use nectin-1 for entry. Immunohistochemistry, real-time PCR, and plaque assays using HSV-1 infected tissues were performed.

Results

We demonstrated that receptor usage by HSV-1 limited to nectin-1 does not significantly change the spread of HSV-1 in the corneal epithelium during primary infection. We also found that nectin-1-specific entry does not affect the capacity of the virus to spread to the TG from the cornea.

Conclusions

Our findings suggest that nectin-1 alone is sufficient for HSV-1 entry into the cornea and spread to the TG."xsd:string
http://purl.uniprot.org/citations/23213272http://purl.uniprot.org/core/author"Valyi-Nagy T."xsd:string
http://purl.uniprot.org/citations/23213272http://purl.uniprot.org/core/author"Tiwari V."xsd:string
http://purl.uniprot.org/citations/23213272http://purl.uniprot.org/core/author"Shukla N.D."xsd:string
http://purl.uniprot.org/citations/23213272http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/23213272http://purl.uniprot.org/core/name"Mol Vis"xsd:string
http://purl.uniprot.org/citations/23213272http://purl.uniprot.org/core/pages"2711-2716"xsd:string
http://purl.uniprot.org/citations/23213272http://purl.uniprot.org/core/title"Nectin-1-specific entry of herpes simplex virus 1 is sufficient for infection of the cornea and viral spread to the trigeminal ganglia."xsd:string
http://purl.uniprot.org/citations/23213272http://purl.uniprot.org/core/volume"18"xsd:string
http://purl.uniprot.org/citations/23213272http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/23213272
http://purl.uniprot.org/citations/23213272http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/23213272
http://purl.uniprot.org/uniprot/#_Q9JKF6-mappedCitation-23213272http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23213272
http://purl.uniprot.org/uniprot/Q9JKF6http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/23213272