| http://purl.uniprot.org/citations/23213453 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23213453 | http://www.w3.org/2000/01/rdf-schema#comment | "By a conserved cellular differentiation process, spermatogenesis leads to formation of haploid sperm for successful reproduction. In Drosophila and in mammals, post-meiotic spermatid differentiation depends on several translationally repressed and stored mRNAs that are often expressed exclusively in the testis through a cell type specific transcriptional program. In Drosophila, the mRNAs of proteins required for post-meiotic chromatin reorganisation, like ProtB and Mst77F, are transcribed in meiotic spermatocytes and subjected to translational repression for days. Transcription of many of these translationally repressed mRNAs depends on testis-specific homologs of TATA box binding protein-associated factors (tTAFs). Here, we identified the testis-specific bromodomain protein, tBRD-1, that is only expressed in primary spermatocytes. Bromodomain proteins are able to recognise and bind acetylated histones and non-histone proteins. We generated tbrd-1 mutant flies and observed that function of tBRD-1 is required for male fertility. tBRD-1 partially colocalised with tTAFs, TAF1 and Polycomb to a Fibrillarin-deficient region within the spermatocyte nucleolus. The nucleolar localisation of tBRD-1 depended on tTAF function but not the other way round. Further, we could show that ectopically expressed tBRD-1-eGFP is able to bind to the interbands of polytene chromosomes. By inhibitor treatment of cultured testis we observed that sub-cellular localisation of tBRD-1 may depend on the acetylation status of primary spermatocytes."xsd:string |
| http://purl.uniprot.org/citations/23213453 | http://purl.org/dc/terms/identifier | "doi:10.1242/bio.20121255"xsd:string |
| http://purl.uniprot.org/citations/23213453 | http://purl.uniprot.org/core/author | "Renkawitz-Pohl R."xsd:string |
| http://purl.uniprot.org/citations/23213453 | http://purl.uniprot.org/core/author | "Rathke C."xsd:string |
| http://purl.uniprot.org/citations/23213453 | http://purl.uniprot.org/core/author | "Leser K."xsd:string |
| http://purl.uniprot.org/citations/23213453 | http://purl.uniprot.org/core/author | "Barckmann B."xsd:string |
| http://purl.uniprot.org/citations/23213453 | http://purl.uniprot.org/core/author | "Awe S."xsd:string |
| http://purl.uniprot.org/citations/23213453 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23213453 | http://purl.uniprot.org/core/name | "Biol Open"xsd:string |
| http://purl.uniprot.org/citations/23213453 | http://purl.uniprot.org/core/pages | "597-606"xsd:string |
| http://purl.uniprot.org/citations/23213453 | http://purl.uniprot.org/core/title | "The bromodomain-containing protein tBRD-1 is specifically expressed in spermatocytes and is essential for male fertility."xsd:string |
| http://purl.uniprot.org/citations/23213453 | http://purl.uniprot.org/core/volume | "1"xsd:string |
| http://purl.uniprot.org/citations/23213453 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23213453 |
| http://purl.uniprot.org/citations/23213453 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23213453 |
| http://purl.uniprot.org/uniprot/Q9VCG6#attribution-E0C78E17C0D9D16ACA9865F849164B15 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23213453 |
| http://purl.uniprot.org/uniprot/Q9VCG6#attribution-F1F0E170944E4488085F59BACBBDC855 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23213453 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6U9-mappedCitation-23213453 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23213453 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4K602-mappedCitation-23213453 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23213453 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LGU9-mappedCitation-23213453 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23213453 |
| http://purl.uniprot.org/uniprot/#_O18412-mappedCitation-23213453 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23213453 |
| http://purl.uniprot.org/uniprot/#_E1JJ72-mappedCitation-23213453 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23213453 |
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| http://purl.uniprot.org/uniprot/#_Q24402-mappedCitation-23213453 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23213453 |