| http://purl.uniprot.org/citations/23217709 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23217709 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23217709 | http://www.w3.org/2000/01/rdf-schema#comment | "The lysosome is a degradative organelle, and its fusion with other organelles is strictly regulated. In contrast to fusion with the late endosome, the mechanisms underlying autophagosome-lysosome fusion remain unknown. Here, we identify syntaxin 17 (Stx17) as the autophagosomal SNARE required for fusion with the endosome/lysosome. Stx17 localizes to the outer membrane of completed autophagosomes but not to the isolation membrane (unclosed intermediate structures); for this reason, the lysosome does not fuse with the isolation membrane. Stx17 interacts with SNAP-29 and the endosomal/lysosomal SNARE VAMP8. Depletion of Stx17 causes accumulation of autophagosomes without degradation. Stx17 has a unique C-terminal hairpin structure mediated by two tandem transmembrane domains containing glycine zipper-like motifs, which is essential for its association with the autophagosomal membrane. These findings reveal a mechanism by which the SNARE protein is available to the completed autophagosome."xsd:string |
| http://purl.uniprot.org/citations/23217709 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2012.11.001"xsd:string |
| http://purl.uniprot.org/citations/23217709 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2012.11.001"xsd:string |
| http://purl.uniprot.org/citations/23217709 | http://purl.uniprot.org/core/author | "Mizushima N."xsd:string |
| http://purl.uniprot.org/citations/23217709 | http://purl.uniprot.org/core/author | "Mizushima N."xsd:string |
| http://purl.uniprot.org/citations/23217709 | http://purl.uniprot.org/core/author | "Itakura E."xsd:string |
| http://purl.uniprot.org/citations/23217709 | http://purl.uniprot.org/core/author | "Itakura E."xsd:string |
| http://purl.uniprot.org/citations/23217709 | http://purl.uniprot.org/core/author | "Kishi-Itakura C."xsd:string |
| http://purl.uniprot.org/citations/23217709 | http://purl.uniprot.org/core/author | "Kishi-Itakura C."xsd:string |
| http://purl.uniprot.org/citations/23217709 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23217709 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23217709 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/23217709 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/23217709 | http://purl.uniprot.org/core/pages | "1256-1269"xsd:string |
| http://purl.uniprot.org/citations/23217709 | http://purl.uniprot.org/core/pages | "1256-1269"xsd:string |
| http://purl.uniprot.org/citations/23217709 | http://purl.uniprot.org/core/title | "The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes."xsd:string |
| http://purl.uniprot.org/citations/23217709 | http://purl.uniprot.org/core/title | "The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes."xsd:string |
| http://purl.uniprot.org/citations/23217709 | http://purl.uniprot.org/core/volume | "151"xsd:string |
| http://purl.uniprot.org/citations/23217709 | http://purl.uniprot.org/core/volume | "151"xsd:string |
| http://purl.uniprot.org/citations/23217709 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23217709 |
| http://purl.uniprot.org/citations/23217709 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23217709 |
| http://purl.uniprot.org/citations/23217709 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23217709 |
| http://purl.uniprot.org/citations/23217709 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23217709 |