| http://purl.uniprot.org/citations/23221571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23221571 | http://www.w3.org/2000/01/rdf-schema#comment | "Actin filament (F-actin) is believed to be involved in measles virus (MV) assembly as a cellular factor, but the precise roles remain unknown. Here we show that Phe at position 50 of the MV matrix (M) protein is important for its association with F-actin, through which the function of the M protein is regulated. In plasmid-expressed or MV-infected cells, a coimmunoprecipitation study revealed that the wild-type M (M-WT) protein associated strongly with F-actin but only weakly with the cytoplasmic tail of the hemagglutinin (H) protein. Since the F50P mutation allowed the M protein the enhanced interaction with the H protein in return for the sharply declined association with F-actin, the mutant M (M-F50P) protein strongly inhibited MV cell-cell fusion and promoted the uptake of the H protein into virus particles. The abundantly incorporated H protein resulted in the increase in infectivity of the F50P virus, although the virus contained a level of genome RNA equal to that of the WT virus. When the structure of F-actin was disrupted with cytochalasin D, the M-WT protein liberated from F-actin interacted with the H protein as tightly as the M-F50P protein, suppressing cell-cell fusion and promoting virus assembly comparably efficiently as the M-F50P protein. The cell-cell fusion activity of the WT virus appeared to be upheld by F-actin, which prevents the M protein interaction with the H protein. Our results indicate that F-actin in association with the M protein alters the interaction between the M and H proteins, thereby modulating MV cell-cell fusion and assembly."xsd:string |
| http://purl.uniprot.org/citations/23221571 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.02371-12"xsd:string |
| http://purl.uniprot.org/citations/23221571 | http://purl.uniprot.org/core/author | "Itoh M."xsd:string |
| http://purl.uniprot.org/citations/23221571 | http://purl.uniprot.org/core/author | "Takeuchi K."xsd:string |
| http://purl.uniprot.org/citations/23221571 | http://purl.uniprot.org/core/author | "Satoh Y."xsd:string |
| http://purl.uniprot.org/citations/23221571 | http://purl.uniprot.org/core/author | "Kitagawa Y."xsd:string |
| http://purl.uniprot.org/citations/23221571 | http://purl.uniprot.org/core/author | "Gotoh B."xsd:string |
| http://purl.uniprot.org/citations/23221571 | http://purl.uniprot.org/core/author | "Wakimoto H."xsd:string |
| http://purl.uniprot.org/citations/23221571 | http://purl.uniprot.org/core/author | "Shimodo M."xsd:string |
| http://purl.uniprot.org/citations/23221571 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23221571 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/23221571 | http://purl.uniprot.org/core/pages | "1974-1984"xsd:string |
| http://purl.uniprot.org/citations/23221571 | http://purl.uniprot.org/core/title | "F-actin modulates measles virus cell-cell fusion and assembly by altering the interaction between the matrix protein and the cytoplasmic tail of hemagglutinin."xsd:string |
| http://purl.uniprot.org/citations/23221571 | http://purl.uniprot.org/core/volume | "87"xsd:string |
| http://purl.uniprot.org/citations/23221571 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23221571 |
| http://purl.uniprot.org/citations/23221571 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23221571 |
| http://purl.uniprot.org/uniprot/#_Q1KLZ0-mappedCitation-23221571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23221571 |
| http://purl.uniprot.org/uniprot/#_A0A510GJR4-mappedCitation-23221571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23221571 |
| http://purl.uniprot.org/uniprot/#_A1E282-mappedCitation-23221571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23221571 |
| http://purl.uniprot.org/uniprot/#_A4UCT3-mappedCitation-23221571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23221571 |
| http://purl.uniprot.org/uniprot/#_A5GZ75-mappedCitation-23221571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23221571 |
| http://purl.uniprot.org/uniprot/#_A0AUL6-mappedCitation-23221571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23221571 |
| http://purl.uniprot.org/uniprot/#_B4DW52-mappedCitation-23221571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23221571 |
| http://purl.uniprot.org/uniprot/#_B4E335-mappedCitation-23221571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23221571 |