| http://purl.uniprot.org/citations/23223235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23223235 | http://www.w3.org/2000/01/rdf-schema#comment | "Prolactin-stimulated adult neurogenesis in the subventricular zone (SVZ) and olfactory bulb (OB) mediates several reproductive behaviors including mating/pregnancy, dominant male pheromone preference in females, and paternal recognition of offspring. However, downstream signaling mechanisms underlying prolactin-induced adult neurogenesis are completely unknown. We report here for the first time that prolactin activates extracellular signal-regulated kinase 5 (ERK5), a MAP kinase that is specifically expressed in the neurogenic regions of the adult mouse brain. Knockdown of ERK5 by retroviral infection of shRNA attenuates prolactin-stimulated neurogenesis in SVZ-derived adult neural stem/progenitor cells (aNPCs). Inducible erk5 deletion in adult neural stem cells of transgenic mice inhibits neurogenesis in the SVZ and OB following prolactin infusion or mating/pregnancy. These results identify ERK5 as a novel and critical signaling mechanism underlying prolactin-induced adult neurogenesis."xsd:string |
| http://purl.uniprot.org/citations/23223235 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m112.401091"xsd:string |
| http://purl.uniprot.org/citations/23223235 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/23223235 | http://purl.uniprot.org/core/author | "Zou J."xsd:string |
| http://purl.uniprot.org/citations/23223235 | http://purl.uniprot.org/core/author | "Xia Z."xsd:string |
| http://purl.uniprot.org/citations/23223235 | http://purl.uniprot.org/core/author | "Kuo C.T."xsd:string |
| http://purl.uniprot.org/citations/23223235 | http://purl.uniprot.org/core/author | "Wietecha T."xsd:string |
| http://purl.uniprot.org/citations/23223235 | http://purl.uniprot.org/core/author | "Pan Y.W."xsd:string |
| http://purl.uniprot.org/citations/23223235 | http://purl.uniprot.org/core/author | "Abel G.M."xsd:string |
| http://purl.uniprot.org/citations/23223235 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23223235 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/23223235 | http://purl.uniprot.org/core/pages | "2623-2631"xsd:string |
| http://purl.uniprot.org/citations/23223235 | http://purl.uniprot.org/core/title | "Extracellular signal-regulated kinase 5 (ERK5) mediates prolactin-stimulated adult neurogenesis in the subventricular zone and olfactory bulb."xsd:string |
| http://purl.uniprot.org/citations/23223235 | http://purl.uniprot.org/core/volume | "288"xsd:string |
| http://purl.uniprot.org/citations/23223235 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23223235 |
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