| http://purl.uniprot.org/citations/23224985 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23224985 | http://www.w3.org/2000/01/rdf-schema#comment | "An essential function of the transcription factors LEF1/TCF4 in cerebral metastases of lung adenocarcinomas has been described in mouse models, suggesting a WNT/β-catenin effect as potential mechanism. Their role in humans is still unclear, thus we analyzed LEF1, TCF4, β-catenin, and early stage prognostic markers in 25 adenocarcinoma brain metastases using immunohistochemistry (IHC). IHC revealed nuclear TCF4 in all adenocarcinoma samples, whereas only 36 % depicted nuclear LEF1 and nuclear β-catenin signals. Samples with nuclear LEF1 as well as high TCF4 (++++) expression were associated with a shorter survival (p = 0.01, HR = 6.68), while nuclear β-catenin had no significant impact on prognosis and did not significantly correlate with nuclear LEF1. High proliferation index Ki67 was associated with shorter survival in late-stage disease (p = 0.03, HR 3.27). Additionally, we generated a LEF1/TCF4 as well as an AXIN2 signature, the latter as representative of WNT/β-catenin activity, following a bioinformatics approach with a gene expression dataset of cerebral metastases in lung adenocarcinoma. To analyze the prognostic relevance in primary lung adenocarcinomas, we applied both signatures to a microarray dataset of 58 primary lung adenocarcinomas. Only the LEF1/TCF4 signature was able to separate clusters with impact on survival (p = 0.01, HR = 0.32). These clusters displayed diverging enrichment patterns of the cell cycle pathway. In conclusion, our data show that LEF1/TCF4, but not β-catenin, have prognostic relevance in primary and cerebrally metastasized human lung adenocarcinomas. In contrast to the previous in vivo findings, these results indicate that LEF1/TCF4 act independently of β-catenin in this setting."xsd:string |
| http://purl.uniprot.org/citations/23224985 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10585-012-9552-7"xsd:string |
| http://purl.uniprot.org/citations/23224985 | http://purl.uniprot.org/core/author | "Kramer F."xsd:string |
| http://purl.uniprot.org/citations/23224985 | http://purl.uniprot.org/core/author | "Stadelmann C."xsd:string |
| http://purl.uniprot.org/citations/23224985 | http://purl.uniprot.org/core/author | "Bleckmann A."xsd:string |
| http://purl.uniprot.org/citations/23224985 | http://purl.uniprot.org/core/author | "Beissbarth T."xsd:string |
| http://purl.uniprot.org/citations/23224985 | http://purl.uniprot.org/core/author | "Pukrop T."xsd:string |
| http://purl.uniprot.org/citations/23224985 | http://purl.uniprot.org/core/author | "Binder C."xsd:string |
| http://purl.uniprot.org/citations/23224985 | http://purl.uniprot.org/core/author | "Klemm F."xsd:string |
| http://purl.uniprot.org/citations/23224985 | http://purl.uniprot.org/core/author | "Rietkotter E."xsd:string |
| http://purl.uniprot.org/citations/23224985 | http://purl.uniprot.org/core/author | "Siam L."xsd:string |
| http://purl.uniprot.org/citations/23224985 | http://purl.uniprot.org/core/author | "Wegner C."xsd:string |
| http://purl.uniprot.org/citations/23224985 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23224985 | http://purl.uniprot.org/core/name | "Clin Exp Metastasis"xsd:string |
| http://purl.uniprot.org/citations/23224985 | http://purl.uniprot.org/core/pages | "471-482"xsd:string |
| http://purl.uniprot.org/citations/23224985 | http://purl.uniprot.org/core/title | "Nuclear LEF1/TCF4 correlate with poor prognosis but not with nuclear beta-catenin in cerebral metastasis of lung adenocarcinomas."xsd:string |
| http://purl.uniprot.org/citations/23224985 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/23224985 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23224985 |
| http://purl.uniprot.org/citations/23224985 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23224985 |
| http://purl.uniprot.org/uniprot/#_A0A0D9SGH8-mappedCitation-23224985 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23224985 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MTL7-mappedCitation-23224985 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23224985 |
| http://purl.uniprot.org/uniprot/#_E2GH26-mappedCitation-23224985 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23224985 |
| http://purl.uniprot.org/uniprot/#_A0A994J711-mappedCitation-23224985 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23224985 |
| http://purl.uniprot.org/uniprot/#_A0A2Z5HTM8-mappedCitation-23224985 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23224985 |