| http://purl.uniprot.org/citations/23225888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23225888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23225888 | http://www.w3.org/2000/01/rdf-schema#comment | "Signaling lymphocytic activation molecule family receptors and the specific adapter signaling lymphocytic activation molecule-associated protein modulate the development of innate-like lymphocytes. In this study, we show that the thymus of Ly9-deficient mice contains an expanded population of CD8 single-positive cells with the characteristic phenotype of innate memory-like CD8(+) T cells. Moreover, the proportion of these innate CD8(+) T cells increased dramatically postinfection with mouse CMV. Gene expression profiling of Ly9-deficient mice thymi showed a significant upregulation of IL-4 and promyelocytic leukemia zinc finger. Analyses of Ly9(-/-)IL4ra(-/-) double-deficient mice revealed that IL-4 was needed to generate the thymic innate CD8(+) T cell subset. Furthermore, increased numbers of invariant NKT cells were detected in Ly9-deficient thymi. In wild-type mice, IL-4 levels induced by α-galactosylceramide injection could be inhibited by a mAb against Ly9. Thus, Ly9 plays a unique role as an inhibitory cell surface receptor regulating the size of the thymic innate CD8(+) T cell pool and the development of invariant NKT cells."xsd:string |
| http://purl.uniprot.org/citations/23225888 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1202435"xsd:string |
| http://purl.uniprot.org/citations/23225888 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1202435"xsd:string |
| http://purl.uniprot.org/citations/23225888 | http://purl.uniprot.org/core/author | "Engel P."xsd:string |
| http://purl.uniprot.org/citations/23225888 | http://purl.uniprot.org/core/author | "Engel P."xsd:string |
| http://purl.uniprot.org/citations/23225888 | http://purl.uniprot.org/core/author | "Angulo A."xsd:string |
| http://purl.uniprot.org/citations/23225888 | http://purl.uniprot.org/core/author | "Angulo A."xsd:string |
| http://purl.uniprot.org/citations/23225888 | http://purl.uniprot.org/core/author | "Terhorst C."xsd:string |
| http://purl.uniprot.org/citations/23225888 | http://purl.uniprot.org/core/author | "Terhorst C."xsd:string |
| http://purl.uniprot.org/citations/23225888 | http://purl.uniprot.org/core/author | "Romero X."xsd:string |
| http://purl.uniprot.org/citations/23225888 | http://purl.uniprot.org/core/author | "Romero X."xsd:string |
| http://purl.uniprot.org/citations/23225888 | http://purl.uniprot.org/core/author | "Bastos R."xsd:string |
| http://purl.uniprot.org/citations/23225888 | http://purl.uniprot.org/core/author | "Bastos R."xsd:string |
| http://purl.uniprot.org/citations/23225888 | http://purl.uniprot.org/core/author | "Cuenca M."xsd:string |
| http://purl.uniprot.org/citations/23225888 | http://purl.uniprot.org/core/author | "Cuenca M."xsd:string |
| http://purl.uniprot.org/citations/23225888 | http://purl.uniprot.org/core/author | "Sintes J."xsd:string |
| http://purl.uniprot.org/citations/23225888 | http://purl.uniprot.org/core/author | "Sintes J."xsd:string |
| http://purl.uniprot.org/citations/23225888 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23225888 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23225888 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/23225888 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/23225888 | http://purl.uniprot.org/core/pages | "21-26"xsd:string |
| http://purl.uniprot.org/citations/23225888 | http://purl.uniprot.org/core/pages | "21-26"xsd:string |