| http://purl.uniprot.org/citations/23229311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23229311 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcription control of multiple genes in tissue- and stage-specific patterns is still of major interest. We show here that troponin I (TNI) is expressed under the control of upstream non-coding sequences and had functions as an isoform of intermediate type between pharynx and body-wall of the gene. In Caenorhabditis elegans, three striated muscle TNIs are expressed in body-wall muscles and a cardiac isoform is expressed in the pharynx. We have analyzed the gene expression mechanisms of tni-3 gene and motility function of its protein product. Promoter deletion analysis of the tni-3 gene identified muscle enhancers including the head enhancer. The CBF1/Su(H)/LAG-1-binding motif was included in the head enhancer. Yeast one-hybrid screening isolated the lag-1 clone in five candidates. Functional differences between the three striated muscle TNIs were investigated by the expression of promoter-fusion genes into tni-2/unc-27(e155) null mutant animals. The results suggest that the cis-elements in the promoters of the three genes are important for their tissue-specific expression and that from the function of TNI-3, the tni-3 gene would be an intermediate in the evolution of these genes by gene duplication. Mechanisms of tni-3 expression and its molecular function may contribute to our understanding of gene evolution and developmental programs."xsd:string |
| http://purl.uniprot.org/citations/23229311 | http://purl.org/dc/terms/identifier | "doi:10.1266/ggs.87.243"xsd:string |
| http://purl.uniprot.org/citations/23229311 | http://purl.uniprot.org/core/author | "Kagawa H."xsd:string |
| http://purl.uniprot.org/citations/23229311 | http://purl.uniprot.org/core/author | "Kitaoka S."xsd:string |
| http://purl.uniprot.org/citations/23229311 | http://purl.uniprot.org/core/author | "Bando T."xsd:string |
| http://purl.uniprot.org/citations/23229311 | http://purl.uniprot.org/core/author | "Takashima Y."xsd:string |
| http://purl.uniprot.org/citations/23229311 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23229311 | http://purl.uniprot.org/core/name | "Genes Genet Syst"xsd:string |
| http://purl.uniprot.org/citations/23229311 | http://purl.uniprot.org/core/pages | "243-251"xsd:string |
| http://purl.uniprot.org/citations/23229311 | http://purl.uniprot.org/core/title | "Expression profiles and unc-27 mutation rescue of the striated muscle type troponin I isoform-3 in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/23229311 | http://purl.uniprot.org/core/volume | "87"xsd:string |
| http://purl.uniprot.org/citations/23229311 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23229311 |
| http://purl.uniprot.org/citations/23229311 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23229311 |
| http://purl.uniprot.org/uniprot/#_Q20334-mappedCitation-23229311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23229311 |
| http://purl.uniprot.org/uniprot/#_Q9XUN9-mappedCitation-23229311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23229311 |
| http://purl.uniprot.org/uniprot/#_Q9GYF1-mappedCitation-23229311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23229311 |
| http://purl.uniprot.org/uniprot/Q20334 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23229311 |
| http://purl.uniprot.org/uniprot/Q9XUN9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23229311 |
| http://purl.uniprot.org/uniprot/Q9GYF1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23229311 |