| http://purl.uniprot.org/citations/23229837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23229837 | http://www.w3.org/2000/01/rdf-schema#comment | "Major depression disorder (MDD) is a complex and chronic disease that ranks fourth as cause of disability worldwide. About 14 million adults in the USA are believed to have MDD, and an estimated 75 % attempt suicide making MDD a major public health problem. Neuroticism has been recognized as an endophenotype of MDD; however, few genome-wide association (GWA) analyses of neuroticism as a quantitative trait have been reported to date. The aim of this study is to identify genome-wide genetic variants affecting neuroticism using a European sample. A linear regression model was used to analyze the association with neuroticism as a continuous trait in the Netherlands Study of Depression and Anxiety and Netherlands Twin Registry population-based sample of 2,748 individuals with Perlegen 600K single nucleotide polymorphisms (SNPs). In addition, the neuroticism-associated genes/loci of the top 20 SNPs (p < 10⁻⁴) were examined with anti-social personality disorder (ASPD) in an Australian twin family study. Through GWA analysis, 32 neuroticism-associated SNPs (p < 10⁻⁴) were identified. The most significant association was observed with SNP rs4806846 within the TMPRSS9 gene (p = 7.79 × 10⁻⁶) at 19p13.3. The next best signal was in GRIN2B gene (rs220549, p = 1.05 × 10⁻⁵) at 12p12. In addition, several SNPs within GRIN2B showed borderline associations with ASPD in the Australian sample. In conclusion, these results provide a possible genetic basis for the association with neuroticism. Our findings provide a basis for replication in other populations to elucidate the potential role of these genetic variants in neuroticism and MDD along with a possible relationship between ASPD and neuroticism."xsd:string |
| http://purl.uniprot.org/citations/23229837 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12031-012-9931-1"xsd:string |
| http://purl.uniprot.org/citations/23229837 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/23229837 | http://purl.uniprot.org/core/author | "Wang K.S."xsd:string |
| http://purl.uniprot.org/citations/23229837 | http://purl.uniprot.org/core/author | "Anderson J.L."xsd:string |
| http://purl.uniprot.org/citations/23229837 | http://purl.uniprot.org/core/author | "Aragam N."xsd:string |
| http://purl.uniprot.org/citations/23229837 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23229837 | http://purl.uniprot.org/core/name | "J Mol Neurosci"xsd:string |
| http://purl.uniprot.org/citations/23229837 | http://purl.uniprot.org/core/pages | "250-256"xsd:string |
| http://purl.uniprot.org/citations/23229837 | http://purl.uniprot.org/core/title | "TMPRSS9 and GRIN2B are associated with neuroticism: a genome-wide association study in a European sample."xsd:string |
| http://purl.uniprot.org/citations/23229837 | http://purl.uniprot.org/core/volume | "50"xsd:string |
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