| http://purl.uniprot.org/citations/23230145 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23230145 | http://www.w3.org/2000/01/rdf-schema#comment | "The tumor suppressors Lats1 and Lats2 are mediators of the Hippo pathway that regulates tissue growth and proliferation. Their N-terminal non-kinase regions are distinct except for Lats conserved domains 1 and 2 (LCD1 and LCD2), which may be important for Lats1/2-specific functions. Lats1 knockout mice were generated by disrupting the N-terminal region containing LCD1 (Lats1(ΔN/ΔN)). Some Lats1(ΔN/ΔN) mice were born safely and grew normally. However, mouse embryonic fibroblasts (MEFs) from Lats1(ΔN/ΔN) mice displayed mitotic defects, centrosomal overduplication, chromosomal misalignment, multipolar spindle formation, chromosomal bridging and cytokinesis failure. They also showed anchorage-independent growth and continued cell cycles and cell growth, bypassing cell-cell contact inhibition similar to tumor cells. Lats1(ΔN/ΔN) MEFs produced tumors in nude mice after subcutaneous injection, although the tumor growth rate was much slower than that of ordinary cancer cells. Yap, a key transcriptional coactivator of the Hippo pathway, was overexpressed and stably retained in Lats1(ΔN/ΔN) MEFs in a cell density independent manner, and Lats2 mRNA expression was downregulated. In conclusion, N-terminally truncated Lats1 induced Lats2 downregulation and Yap protein accumulation, leading to chromosomal instability and tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/23230145 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.113431"xsd:string |
| http://purl.uniprot.org/citations/23230145 | http://purl.uniprot.org/core/author | "Ito A."xsd:string |
| http://purl.uniprot.org/citations/23230145 | http://purl.uniprot.org/core/author | "Ikawa M."xsd:string |
| http://purl.uniprot.org/citations/23230145 | http://purl.uniprot.org/core/author | "Nojima H."xsd:string |
| http://purl.uniprot.org/citations/23230145 | http://purl.uniprot.org/core/author | "Okamoto A."xsd:string |
| http://purl.uniprot.org/citations/23230145 | http://purl.uniprot.org/core/author | "Suzuki H."xsd:string |
| http://purl.uniprot.org/citations/23230145 | http://purl.uniprot.org/core/author | "Yoshida K."xsd:string |
| http://purl.uniprot.org/citations/23230145 | http://purl.uniprot.org/core/author | "Okada N."xsd:string |
| http://purl.uniprot.org/citations/23230145 | http://purl.uniprot.org/core/author | "Okabe M."xsd:string |
| http://purl.uniprot.org/citations/23230145 | http://purl.uniprot.org/core/author | "Miura D."xsd:string |
| http://purl.uniprot.org/citations/23230145 | http://purl.uniprot.org/core/author | "Okuzaki D."xsd:string |
| http://purl.uniprot.org/citations/23230145 | http://purl.uniprot.org/core/author | "Yabuta N."xsd:string |
| http://purl.uniprot.org/citations/23230145 | http://purl.uniprot.org/core/author | "Mukai S."xsd:string |
| http://purl.uniprot.org/citations/23230145 | http://purl.uniprot.org/core/author | "Torigata K."xsd:string |
| http://purl.uniprot.org/citations/23230145 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23230145 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/23230145 | http://purl.uniprot.org/core/pages | "508-520"xsd:string |
| http://purl.uniprot.org/citations/23230145 | http://purl.uniprot.org/core/title | "N-terminal truncation of Lats1 causes abnormal cell growth control and chromosomal instability."xsd:string |
| http://purl.uniprot.org/citations/23230145 | http://purl.uniprot.org/core/volume | "126"xsd:string |
| http://purl.uniprot.org/citations/23230145 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23230145 |
| http://purl.uniprot.org/citations/23230145 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23230145 |
| http://purl.uniprot.org/uniprot/#_G3UWQ0-mappedCitation-23230145 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23230145 |
| http://purl.uniprot.org/uniprot/#_G3UXX1-mappedCitation-23230145 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23230145 |