| http://purl.uniprot.org/citations/23234877 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23234877 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously reported TOMM40 was significantly down-regulated in whole blood of Alzheimer's disease (AD) subjects. In this study, we examined whole blood gene profiling differences over a one-year period comparing early AD subjects based on disease progression. 6-monthly assessments and blood sampling on 29 probable AD subjects compared with age- and gender-matched controls were performed. AD subjects with change in Clinical Dementia Rating-Sum of Boxes (CDR-SB) score of ≥2 points/year were classified as fast-progressors and those with CDR-SB change of <2 points/year were classified as slow-progressors. We found statistically significant upregulation in KIR2DL5A, SLC2A8, and PLOD1 for fast-(n = 8) compared with slow-progressors (n = 21) across the time-points. TOMM40 gene expression remained significantly lower in AD patients at all time-points compared to controls, supporting our previous findings. Our novel findings of specific gene expression differences between fast- and slow-progressors in combination with consistently lower TOMM40 expression, suggest their potential role as prognostic blood biomarkers to predict progression in early AD."xsd:string |
| http://purl.uniprot.org/citations/23234877 | http://purl.org/dc/terms/identifier | "doi:10.3233/jad-121621"xsd:string |
| http://purl.uniprot.org/citations/23234877 | http://purl.uniprot.org/core/author | "Chen G."xsd:string |
| http://purl.uniprot.org/citations/23234877 | http://purl.uniprot.org/core/author | "Feng L."xsd:string |
| http://purl.uniprot.org/citations/23234877 | http://purl.uniprot.org/core/author | "Tan C.H."xsd:string |
| http://purl.uniprot.org/citations/23234877 | http://purl.uniprot.org/core/author | "Chan M."xsd:string |
| http://purl.uniprot.org/citations/23234877 | http://purl.uniprot.org/core/author | "Ng T.P."xsd:string |
| http://purl.uniprot.org/citations/23234877 | http://purl.uniprot.org/core/author | "Lee T.S."xsd:string |
| http://purl.uniprot.org/citations/23234877 | http://purl.uniprot.org/core/author | "Goh L.K."xsd:string |
| http://purl.uniprot.org/citations/23234877 | http://purl.uniprot.org/core/author | "Lim W.S."xsd:string |
| http://purl.uniprot.org/citations/23234877 | http://purl.uniprot.org/core/author | "Chong M.S."xsd:string |
| http://purl.uniprot.org/citations/23234877 | http://purl.uniprot.org/core/author | "Tay L."xsd:string |
| http://purl.uniprot.org/citations/23234877 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23234877 | http://purl.uniprot.org/core/name | "J Alzheimers Dis"xsd:string |
| http://purl.uniprot.org/citations/23234877 | http://purl.uniprot.org/core/pages | "399-405"xsd:string |
| http://purl.uniprot.org/citations/23234877 | http://purl.uniprot.org/core/title | "Gene expression profiling of peripheral blood leukocytes shows consistent longitudinal downregulation of TOMM40 and upregulation of KIR2DL5A, PLOD1, and SLC2A8 among fast progressors in early Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/23234877 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/23234877 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23234877 |
| http://purl.uniprot.org/citations/23234877 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23234877 |
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| http://purl.uniprot.org/uniprot/#_A0A330IXA5-mappedCitation-23234877 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23234877 |
| http://purl.uniprot.org/uniprot/#_A0A191URI1-mappedCitation-23234877 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23234877 |
| http://purl.uniprot.org/uniprot/#_A0A376A8X2-mappedCitation-23234877 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23234877 |
| http://purl.uniprot.org/uniprot/#_B2R5M9-mappedCitation-23234877 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23234877 |