| http://purl.uniprot.org/citations/23238728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23238728 | http://www.w3.org/2000/01/rdf-schema#comment | "A kinase-anchoring proteins (AKAPs) organize compartmentalized pools of protein kinase A (PKA) to enable localized signaling events within neurons. However, it is unclear which of the many expressed AKAPs in neurons target PKA to signaling complexes important for long-lasting forms of synaptic plasticity and memory storage. In the forebrain, the anchoring protein gravin recruits a signaling complex containing PKA, PKC, calmodulin, and PDE4D (phosphodiesterase 4D) to the β2-adrenergic receptor. Here, we show that mice lacking the α-isoform of gravin have deficits in PKA-dependent long-lasting forms of hippocampal synaptic plasticity including β2-adrenergic receptor-mediated plasticity, and selective impairments of long-term memory storage. Furthermore, both hippocampal β2-adrenergic receptor phosphorylation by PKA, and learning-induced activation of ERK in the CA1 region of the hippocampus are attenuated in mice lacking gravin-α. We conclude that gravin compartmentalizes a significant pool of PKA that regulates learning-induced β2-adrenergic receptor signaling and ERK activation in the hippocampus in vivo, thereby organizing molecular interactions between glutamatergic and noradrenergic signaling pathways for long-lasting synaptic plasticity, and memory storage."xsd:string |
| http://purl.uniprot.org/citations/23238728 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.3612-12.2012"xsd:string |
| http://purl.uniprot.org/citations/23238728 | http://purl.uniprot.org/core/author | "Huang T."xsd:string |
| http://purl.uniprot.org/citations/23238728 | http://purl.uniprot.org/core/author | "Scott J.D."xsd:string |
| http://purl.uniprot.org/citations/23238728 | http://purl.uniprot.org/core/author | "Park A.J."xsd:string |
| http://purl.uniprot.org/citations/23238728 | http://purl.uniprot.org/core/author | "Abel T."xsd:string |
| http://purl.uniprot.org/citations/23238728 | http://purl.uniprot.org/core/author | "Luczak V."xsd:string |
| http://purl.uniprot.org/citations/23238728 | http://purl.uniprot.org/core/author | "Nie T."xsd:string |
| http://purl.uniprot.org/citations/23238728 | http://purl.uniprot.org/core/author | "Baillie G.S."xsd:string |
| http://purl.uniprot.org/citations/23238728 | http://purl.uniprot.org/core/author | "Gelman I.H."xsd:string |
| http://purl.uniprot.org/citations/23238728 | http://purl.uniprot.org/core/author | "Day J.P."xsd:string |
| http://purl.uniprot.org/citations/23238728 | http://purl.uniprot.org/core/author | "Canton D.A."xsd:string |
| http://purl.uniprot.org/citations/23238728 | http://purl.uniprot.org/core/author | "Havekes R."xsd:string |
| http://purl.uniprot.org/citations/23238728 | http://purl.uniprot.org/core/author | "Grimes Q."xsd:string |
| http://purl.uniprot.org/citations/23238728 | http://purl.uniprot.org/core/author | "Guercio L.A."xsd:string |
| http://purl.uniprot.org/citations/23238728 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23238728 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/23238728 | http://purl.uniprot.org/core/pages | "18137-18149"xsd:string |
| http://purl.uniprot.org/citations/23238728 | http://purl.uniprot.org/core/title | "Gravin orchestrates protein kinase A and beta2-adrenergic receptor signaling critical for synaptic plasticity and memory."xsd:string |
| http://purl.uniprot.org/citations/23238728 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/23238728 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23238728 |
| http://purl.uniprot.org/citations/23238728 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23238728 |
| http://purl.uniprot.org/uniprot/Q9WTQ5#attribution-B64AEB1E3493168AD387F060C4F277EF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23238728 |
| http://purl.uniprot.org/uniprot/#_A0A668KLD3-mappedCitation-23238728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23238728 |