| http://purl.uniprot.org/citations/23246435 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23246435 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23246435 | http://www.w3.org/2000/01/rdf-schema#comment | "RNA-mediated transcriptional silencing prevents deleterious effects of transposon activity and controls the expression of protein-coding genes. It involves long noncoding RNAs (lncRNAs). In Arabidopsis thaliana, some of those lncRNAs are produced by a specialized RNA Polymerase V (Pol V). The mechanism by which lncRNAs affect chromatin structure and mRNA production remains mostly unknown. Here we identify the SWI/SNF ATP-dependent nucleosome-remodeling complex as a component of the RNA-mediated transcriptional silencing pathway. We found that SWI3B, an essential subunit of the SWI/SNF complex, physically interacts with a lncRNA-binding protein, IDN2. SWI/SNF subunits contribute to lncRNA-mediated transcriptional silencing. Moreover, Pol V mediates stabilization of nucleosomes on silenced regions. We propose that Pol V-produced lncRNAs mediate transcriptional silencing by guiding the SWI/SNF complex and establishing positioned nucleosomes on specific genomic loci. We further propose that guiding ATP-dependent chromatin-remodeling complexes may be a more general function of lncRNAs."xsd:string |
| http://purl.uniprot.org/citations/23246435 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2012.11.011"xsd:string |
| http://purl.uniprot.org/citations/23246435 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2012.11.011"xsd:string |
| http://purl.uniprot.org/citations/23246435 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/23246435 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/23246435 | http://purl.uniprot.org/core/author | "Rowley M.J."xsd:string |
| http://purl.uniprot.org/citations/23246435 | http://purl.uniprot.org/core/author | "Rowley M.J."xsd:string |
| http://purl.uniprot.org/citations/23246435 | http://purl.uniprot.org/core/author | "Wierzbicki A.T."xsd:string |
| http://purl.uniprot.org/citations/23246435 | http://purl.uniprot.org/core/author | "Wierzbicki A.T."xsd:string |
| http://purl.uniprot.org/citations/23246435 | http://purl.uniprot.org/core/author | "Bohmdorfer G."xsd:string |
| http://purl.uniprot.org/citations/23246435 | http://purl.uniprot.org/core/author | "Bohmdorfer G."xsd:string |
| http://purl.uniprot.org/citations/23246435 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23246435 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23246435 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/23246435 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/23246435 | http://purl.uniprot.org/core/pages | "298-309"xsd:string |
| http://purl.uniprot.org/citations/23246435 | http://purl.uniprot.org/core/pages | "298-309"xsd:string |
| http://purl.uniprot.org/citations/23246435 | http://purl.uniprot.org/core/title | "A SWI/SNF chromatin-remodeling complex acts in noncoding RNA-mediated transcriptional silencing."xsd:string |
| http://purl.uniprot.org/citations/23246435 | http://purl.uniprot.org/core/title | "A SWI/SNF chromatin-remodeling complex acts in noncoding RNA-mediated transcriptional silencing."xsd:string |
| http://purl.uniprot.org/citations/23246435 | http://purl.uniprot.org/core/volume | "49"xsd:string |
| http://purl.uniprot.org/citations/23246435 | http://purl.uniprot.org/core/volume | "49"xsd:string |
| http://purl.uniprot.org/citations/23246435 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23246435 |
| http://purl.uniprot.org/citations/23246435 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23246435 |