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| http://purl.uniprot.org/citations/23246967 | http://www.w3.org/2000/01/rdf-schema#comment | "The androgen receptor (AR) has a vital role in the onset and progression of prostate cancer by promoting G1-S progression, possibly by functioning as a licensing factor for DNA replication. We here report that low dose 2-methoxyestradiol (2-ME), an endogenous estrogen metabolite, induces mitotic arrest in prostate cancer cells involving activation of the E3 ligase CHIP (C-terminus of Hsp70-interacting protein) and degradation of the AR. Depletion of the AR by small interfering RNA (siRNA) eliminates 2-ME-induced arrest and introducing AR into PC3-M cells confers 2-ME-induced mitotic arrest. Knockdown of CHIP or MDM2 (mouse homolog of double minute 2 protein) individually or in combination reduced AR degradation and abrogated M phase arrest induced by 2-ME. Our data link AR degradation via ubiquitination to mitotic arrest. Targeting the AR by activating E3 ligases such as CHIP represents a novel strategy for the treatment of prostate cancer."xsd:string |
| http://purl.uniprot.org/citations/23246967 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2012.561"xsd:string |
| http://purl.uniprot.org/citations/23246967 | http://purl.uniprot.org/core/author | "Sarkar S."xsd:string |
| http://purl.uniprot.org/citations/23246967 | http://purl.uniprot.org/core/author | "Brautigan D.L."xsd:string |
| http://purl.uniprot.org/citations/23246967 | http://purl.uniprot.org/core/author | "Parsons S.J."xsd:string |
| http://purl.uniprot.org/citations/23246967 | http://purl.uniprot.org/core/author | "Larner J.M."xsd:string |
| http://purl.uniprot.org/citations/23246967 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/23246967 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/23246967 | http://purl.uniprot.org/core/pages | "26-33"xsd:string |
| http://purl.uniprot.org/citations/23246967 | http://purl.uniprot.org/core/title | "Androgen receptor degradation by the E3 ligase CHIP modulates mitotic arrest in prostate cancer cells."xsd:string |
| http://purl.uniprot.org/citations/23246967 | http://purl.uniprot.org/core/volume | "33"xsd:string |
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