| http://purl.uniprot.org/citations/23247197 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23247197 | http://www.w3.org/2000/01/rdf-schema#comment | "In this study, we investigated the role of c-Myc/ATF4/CHOP signaling pathway in sensitization of human hepatoma HepG2 cells to TRAIL. Knockdown of SIRT1 or treatment with SIRT1 inhibitor caused the up-regulation of DR5 and down-regulation of c-FLIP through modulation of c-Myc/ATF4/CHOP pathway, and subsequently enhanced the cytotoxic and apoptotic effects of TRAIL on HepG2 cells. Interestingly, SIRT1 interacted directly with c-FLIP(L) and Ku70, and treatment with SIRT1 inhibitor enhanced acetylation of Ku70 and subsequently decreased its binding to c-FLIP. And this was followed by degradation of c-FLIP. Moreover, Ku70(-/-) MEF and Ku70-knockdown HepG2 cells showed the increased levels of c-Myc, ATF4, CHOP, and DR5 and decreased level of c-FLIP. These results were followed by increased sensitivity of Ku70(-/-) MEF cells and Ku70-knockdown HepG2 cells to TRAIL compared with their control cells. These findings reveal for the first time that SIRT1 inhibition increases Ku70 acetylation, and the acetylated Ku70 with a decreased function mediates the induction of DR5 and the down-regulation of c-FLIP by up-regulating c-Myc/ATF4/CHOP pathway, and consequently promotes the TRAIL-induced apoptosis of HepG2 cells. This study provides important mechanistic insight of the synergism exhibited by SIRT1 inhibition and TRAIL."xsd:string |
| http://purl.uniprot.org/citations/23247197 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.biocel.2012.12.005"xsd:string |
| http://purl.uniprot.org/citations/23247197 | http://purl.uniprot.org/core/author | "Kim S.H."xsd:string |
| http://purl.uniprot.org/citations/23247197 | http://purl.uniprot.org/core/author | "Lee S.H."xsd:string |
| http://purl.uniprot.org/citations/23247197 | http://purl.uniprot.org/core/author | "Kim D.W."xsd:string |
| http://purl.uniprot.org/citations/23247197 | http://purl.uniprot.org/core/author | "Kim M.J."xsd:string |
| http://purl.uniprot.org/citations/23247197 | http://purl.uniprot.org/core/author | "Bae J.H."xsd:string |
| http://purl.uniprot.org/citations/23247197 | http://purl.uniprot.org/core/author | "Oh W.K."xsd:string |
| http://purl.uniprot.org/citations/23247197 | http://purl.uniprot.org/core/author | "Kim H.B."xsd:string |
| http://purl.uniprot.org/citations/23247197 | http://purl.uniprot.org/core/author | "Dao T.T."xsd:string |
| http://purl.uniprot.org/citations/23247197 | http://purl.uniprot.org/core/author | "Kang C.D."xsd:string |
| http://purl.uniprot.org/citations/23247197 | http://purl.uniprot.org/core/author | "Hong K.S."xsd:string |
| http://purl.uniprot.org/citations/23247197 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23247197 | http://purl.uniprot.org/core/name | "Int J Biochem Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/23247197 | http://purl.uniprot.org/core/pages | "711-723"xsd:string |
| http://purl.uniprot.org/citations/23247197 | http://purl.uniprot.org/core/title | "Ku70 acetylation and modulation of c-Myc/ATF4/CHOP signaling axis by SIRT1 inhibition lead to sensitization of HepG2 cells to TRAIL through induction of DR5 and down-regulation of c-FLIP."xsd:string |
| http://purl.uniprot.org/citations/23247197 | http://purl.uniprot.org/core/volume | "45"xsd:string |
| http://purl.uniprot.org/citations/23247197 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23247197 |
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