| http://purl.uniprot.org/citations/23248269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23248269 | http://www.w3.org/2000/01/rdf-schema#comment | "Parasitic helminths are a major cause of chronic human disease, affecting more than 3 billion people worldwide. Host protection against most parasitic helminths relies upon Type 2 cytokine production, but the mechanisms that regulate interleukin (IL) 4 and 13 production from CD4(+) T helper 2 cells (T(H)2) and innate lymphoid type 2 cells (ILC2s) remain incompletely understood. The epithelial cell-derived cytokines IL-25 and IL-33 promote Type 2 responses, but the extent of functional redundancy between these cytokines is unclear and whether Type 2 memory relies upon either IL-25 or IL-33 is unknown. Herein, we demonstrate a pivotal role for IL-33 in driving primary and anamnestic immunity against the rodent hookworm Nippostrongylus brasiliensis. IL-33-deficient mice have a selective defect in ILC2-derived IL-13 during both primary and secondary challenge infections but generate stronger canonical CD4(+) T helper 2 cells responses (IL-4, IgE, mast cells, and basophils) than WT controls. Lack of IL-13 production in IL-33-deficient mice impairs resistin-like molecule beta (RELMβ) expression and eosinophil recruitment, which are two mechanisms that eliminate N. brasiliensis parasites from infected hosts. Thus, IL-33 is requisite for IL-13 but not IL-4-driven Type 2 responses during hookworm infection."xsd:string |
| http://purl.uniprot.org/citations/23248269 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1206587110"xsd:string |
| http://purl.uniprot.org/citations/23248269 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/23248269 | http://purl.uniprot.org/core/author | "Smith D.E."xsd:string |
| http://purl.uniprot.org/citations/23248269 | http://purl.uniprot.org/core/author | "Herbert D.R."xsd:string |
| http://purl.uniprot.org/citations/23248269 | http://purl.uniprot.org/core/author | "Downey J."xsd:string |
| http://purl.uniprot.org/citations/23248269 | http://purl.uniprot.org/core/author | "Hung L.Y."xsd:string |
| http://purl.uniprot.org/citations/23248269 | http://purl.uniprot.org/core/author | "Lewkowich I.P."xsd:string |
| http://purl.uniprot.org/citations/23248269 | http://purl.uniprot.org/core/author | "Dawson L.A."xsd:string |
| http://purl.uniprot.org/citations/23248269 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23248269 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/23248269 | http://purl.uniprot.org/core/pages | "282-287"xsd:string |
| http://purl.uniprot.org/citations/23248269 | http://purl.uniprot.org/core/title | "IL-33 drives biphasic IL-13 production for noncanonical Type 2 immunity against hookworms."xsd:string |
| http://purl.uniprot.org/citations/23248269 | http://purl.uniprot.org/core/volume | "110"xsd:string |
| http://purl.uniprot.org/citations/23248269 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23248269 |
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