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| http://purl.uniprot.org/citations/23248330 | http://www.w3.org/2000/01/rdf-schema#comment | "We used a mouse C57BL/6J×CASA/Rk intercross to map a locus on chromosome 14 that displayed a gender-dependent effect on cholesterol absorption from the intestine. Studies in congenic animals revealed a complex locus with multiple operating genetic determinants resulting in alternating gender-dependent phenotypic effects. Fine-mapping narrowed the locus to a critical 6.3 Mb interval. Female subcongenics, but not males, of the critical interval displayed a decrease of 33% in cholesterol absorption. RNA-Seq analysis of female subcongenic jejunum revealed that cysteine protease cathepsin B (Ctsb) is a candidate to explain the interval effect. Consistent with the phenotype in critical interval subcongenics, female Ctsb knockout mice, but not males, displayed a decrease of 31% in cholesterol absorption. Although studies in Ctsb knockouts revealed a gender-dependent effect on cholesterol absorption, further fine-mapping dismissed a role for Ctsb in determining the effect of the critical 6.3 Mb interval on cholesterol absorption."xsd:string |
| http://purl.uniprot.org/citations/23248330 | http://purl.org/dc/terms/identifier | "doi:10.1194/jlr.m034579"xsd:string |
| http://purl.uniprot.org/citations/23248330 | http://purl.uniprot.org/core/author | "Cote J.F."xsd:string |
| http://purl.uniprot.org/citations/23248330 | http://purl.uniprot.org/core/author | "Wong W.P.S."xsd:string |
| http://purl.uniprot.org/citations/23248330 | http://purl.uniprot.org/core/author | "Sehayek E."xsd:string |
| http://purl.uniprot.org/citations/23248330 | http://purl.uniprot.org/core/author | "Serre D."xsd:string |
| http://purl.uniprot.org/citations/23248330 | http://purl.uniprot.org/core/author | "Chan E.R."xsd:string |
| http://purl.uniprot.org/citations/23248330 | http://purl.uniprot.org/core/author | "Altemus J.B."xsd:string |
| http://purl.uniprot.org/citations/23248330 | http://purl.uniprot.org/core/author | "Hester J.F."xsd:string |
| http://purl.uniprot.org/citations/23248330 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23248330 | http://purl.uniprot.org/core/name | "J Lipid Res"xsd:string |
| http://purl.uniprot.org/citations/23248330 | http://purl.uniprot.org/core/pages | "816-822"xsd:string |
| http://purl.uniprot.org/citations/23248330 | http://purl.uniprot.org/core/title | "Cathepsin B is a novel gender-dependent determinant of cholesterol absorption from the intestine."xsd:string |
| http://purl.uniprot.org/citations/23248330 | http://purl.uniprot.org/core/volume | "54"xsd:string |
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