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Background

The prognostic significance of immunocytochemical analysis of tumour vascular endothelial growth factor (VEGF) and its 2 receptors, VEGF-R1 and VEGF-R2, remains incompletely investigated in patients with oesophagogastric cancer.


Methods

Patients undergoing surgical resection were prospectively recruited between February 1999 and August 2000. Immunocytochemical analysis of VEGF, VEGF-R1 (Flt-1) and VEGF-R2 (Flk-1/KDR) was undertaken using validated techniques. Patients were followed up over a 10-year period using the Northern Ireland Cancer Registry.


Results

Sixty-one patients were recruited (male=45, 73.8%) with a median age of 66.0 years (range 39-83). Forty-seven (77.0%) adenocarcinomas and 14 (23.0%) squamous cell carcinomas were resected. UICC tumour staging was: stage I=14.7%, II=24.6%, III=54.1% and IV=6.6%. VEGF, VEGF-R1 and VEGF-R2 were over-expressed in tumour epithelial cells. VEGF-R2 expression was decreased in the presence of lymphovascular invasion and higher tumour grade. The 10-year survival rate was 19.7% (n=12) with a median follow-up of 808 (IQR 356-2313) days. On univariate analysis only lymphovascular invasion significantly predicted poor prognosis in this cohort (p=0.05). 


Conclusion

VEGF, VEGF-R1 and VEGF-R2 were over-expressed in tumour epithelial cells. VEGF-R2 expression was decreased in the presence of more aggressive pathological variables. Larger studies are required to assess the prognostic significance of these biomarkers in oesophagogastric cancer."xsd:string
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http://purl.uniprot.org/citations/23250775http://purl.uniprot.org/core/author"O'Donnell M.E."xsd:string
http://purl.uniprot.org/citations/23250775http://purl.uniprot.org/core/author"Maxwell P."xsd:string
http://purl.uniprot.org/citations/23250775http://purl.uniprot.org/core/author"McGuigan J.A."xsd:string
http://purl.uniprot.org/citations/23250775http://purl.uniprot.org/core/author"Gray R.T."xsd:string
http://purl.uniprot.org/citations/23250775http://purl.uniprot.org/core/author"Spence G.M."xsd:string
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http://purl.uniprot.org/citations/23250775http://purl.uniprot.org/core/title"Long-term follow-up of immunocytochemical analysis of vascular endothelial growth factor (VEGF), and its two receptors, VEGF-R1 (Flt-1) and VEGF-R2 (Flk-1/KDR), in oesophagogastric cancer."xsd:string
http://purl.uniprot.org/citations/23250775http://purl.uniprot.org/core/volume"28"xsd:string
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