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http://purl.uniprot.org/citations/23253688http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23253688http://www.w3.org/2000/01/rdf-schema#comment"

Background

Interleukin-1 (IL-1) seems to have an important role in early reactions towards microbes, while its genetic variability could affect this role in atopic patients who have a distressed immunity towards dermatological infections.

Methods

Eighty-nine patients with atopic dermatitis (AD), who were referred to a main referral paediatric hospital, were enrolled in this study. Single nucleotide polymorphisms (SNP) of the following IL-1 cluster genes were assessed in this group of patients: IL-1α -889, IL-1β -511, IL-1β +3962, IL-1R Pst-I 1970, and IL-1RA Mspa-I 11100. The results were compared with a group of 140 healthy subjects from the same region.

Results

Fourteen percent of the controls had TT homozygous genotype in IL-1R at position Pst-I 1970, while only 2% of the patients with AD had this genotype (p=0.005, OR: 0.14, 95%CI: 0.02-0.64). The CC homozygous genotype was the most common genotype in IL-1α position -889 and IL-1β at position +3962 in both groups of patients with AD and the controls, while the TC heterozygous genotype was the most common genotype in IL-1β at position -511 and IL-1R at position Pst-I 1970, with no significant difference between the two groups.

Conclusions

This study showed a significant negative association in the IL-1R Mspa-I 11100 TT homozygous genotype in the patients with AD."xsd:string
http://purl.uniprot.org/citations/23253688http://purl.org/dc/terms/identifier"doi:10.1016/j.aller.2012.09.005"xsd:string
http://purl.uniprot.org/citations/23253688http://purl.uniprot.org/core/author"Amirzargar A.A."xsd:string
http://purl.uniprot.org/citations/23253688http://purl.uniprot.org/core/author"Rezaei N."xsd:string
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http://purl.uniprot.org/citations/23253688http://purl.uniprot.org/core/author"Mahmoudi M."xsd:string
http://purl.uniprot.org/citations/23253688http://purl.uniprot.org/core/author"Gharagozlou M."xsd:string
http://purl.uniprot.org/citations/23253688http://purl.uniprot.org/core/author"Farhadi E."xsd:string
http://purl.uniprot.org/citations/23253688http://purl.uniprot.org/core/author"Behniafard N."xsd:string
http://purl.uniprot.org/citations/23253688http://purl.uniprot.org/core/author"Darabi B."xsd:string
http://purl.uniprot.org/citations/23253688http://purl.uniprot.org/core/author"Fathi S.M."xsd:string
http://purl.uniprot.org/citations/23253688http://purl.uniprot.org/core/author"Khaledi M."xsd:string
http://purl.uniprot.org/citations/23253688http://purl.uniprot.org/core/author"Moghaddam Z.G."xsd:string
http://purl.uniprot.org/citations/23253688http://purl.uniprot.org/core/author"Sotoudeh S."xsd:string
http://purl.uniprot.org/citations/23253688http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/23253688http://purl.uniprot.org/core/name"Allergol Immunopathol (Madr)"xsd:string
http://purl.uniprot.org/citations/23253688http://purl.uniprot.org/core/pages"212-215"xsd:string
http://purl.uniprot.org/citations/23253688http://purl.uniprot.org/core/title"Association of single nucleotide polymorphisms of interleukin-1 family with atopic dermatitis."xsd:string
http://purl.uniprot.org/citations/23253688http://purl.uniprot.org/core/volume"42"xsd:string
http://purl.uniprot.org/citations/23253688http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/23253688
http://purl.uniprot.org/citations/23253688http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/23253688
http://purl.uniprot.org/uniprot/#_B8ZZW4-mappedCitation-23253688http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23253688
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