| http://purl.uniprot.org/citations/23255108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23255108 | http://www.w3.org/2000/01/rdf-schema#comment | "Loss of function in either VHL or Nek1 leads to cyst formation in tissues, especially in kidneys. Whether there is a connection between pVHL and Nek1 regulation is unknown. Here, we report that the VHL protein (pVHL) may be a substrate of Nek1. While Nek1 can phosphorylate pVHL at multiple sites, the phosphorylation at serine-168 results in pVHL degradation. Nek1-mediated phosphorylation of pVHL does not significantly affect hypoxia-inducible factors (HIF), a known target of pVHL. However, non-phosphorylable pVHL reconstituted in VHL-deficient cells induces more stable cilia than wild-type VHL during serum stimulation and Nocodazole treatment. The results suggest a possible regulation of pVHL by Nek1 that may contribute to ciliary homeostasis and cystogenesis."xsd:string |
| http://purl.uniprot.org/citations/23255108 | http://purl.org/dc/terms/identifier | "doi:10.4161/cc.23053"xsd:string |
| http://purl.uniprot.org/citations/23255108 | http://purl.uniprot.org/core/author | "Dong Z."xsd:string |
| http://purl.uniprot.org/citations/23255108 | http://purl.uniprot.org/core/author | "Huang S."xsd:string |
| http://purl.uniprot.org/citations/23255108 | http://purl.uniprot.org/core/author | "Pabla N."xsd:string |
| http://purl.uniprot.org/citations/23255108 | http://purl.uniprot.org/core/author | "Patil M."xsd:string |
| http://purl.uniprot.org/citations/23255108 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23255108 | http://purl.uniprot.org/core/name | "Cell Cycle"xsd:string |
| http://purl.uniprot.org/citations/23255108 | http://purl.uniprot.org/core/pages | "166-171"xsd:string |
| http://purl.uniprot.org/citations/23255108 | http://purl.uniprot.org/core/title | "Nek1 phosphorylates Von Hippel-Lindau tumor suppressor to promote its proteasomal degradation and ciliary destabilization."xsd:string |
| http://purl.uniprot.org/citations/23255108 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/23255108 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23255108 |
| http://purl.uniprot.org/citations/23255108 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23255108 |
| http://purl.uniprot.org/uniprot/#_A0A024R2F2-mappedCitation-23255108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23255108 |
| http://purl.uniprot.org/uniprot/#_A4ZYX2-mappedCitation-23255108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23255108 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4K1-mappedCitation-23255108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23255108 |
| http://purl.uniprot.org/uniprot/#_B4E1V7-mappedCitation-23255108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23255108 |
| http://purl.uniprot.org/uniprot/#_A0PJF6-mappedCitation-23255108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23255108 |
| http://purl.uniprot.org/uniprot/#_I6RYK4-mappedCitation-23255108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23255108 |
| http://purl.uniprot.org/uniprot/#_Q15453-mappedCitation-23255108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23255108 |
| http://purl.uniprot.org/uniprot/#_J9Z661-mappedCitation-23255108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23255108 |
| http://purl.uniprot.org/uniprot/#_Q5JXL9-mappedCitation-23255108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23255108 |
| http://purl.uniprot.org/uniprot/#_P40337-mappedCitation-23255108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23255108 |
| http://purl.uniprot.org/uniprot/#_Q9UMS7-mappedCitation-23255108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23255108 |