| http://purl.uniprot.org/citations/23260145 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23260145 | http://www.w3.org/2000/01/rdf-schema#comment | "Most studies on TCF7L2 SNP variants in the pathogenesis of type 2 diabetes (T2D) focus on a role of the encoded transcription factor TCF4 in β cells. Here, a mouse genetics approach shows that removal of TCF4 from β cells does not affect their function, whereas manipulating TCF4 levels in the liver has major effects on metabolism. In Tcf7l2(-/-) mice, the immediate postnatal surge in liver metabolism does not occur. Consequently, pups die due to hypoglycemia. By combining chromatin immunoprecipitation with gene expression profiling, we identify a TCF4-controlled metabolic gene program that is acutely activated in the postnatal liver. In concordance, adult liver-specific Tcf7l2 knockout mice show reduced hepatic glucose production during fasting and display improved glucose homeostasis when maintained on high-fat diet. Furthermore, liver-specific TCF4 overexpression increases hepatic glucose production. These observations imply that TCF4 directly activates metabolic genes and that inhibition of Wnt signaling may be beneficial in metabolic disease."xsd:string |
| http://purl.uniprot.org/citations/23260145 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2012.10.053"xsd:string |
| http://purl.uniprot.org/citations/23260145 | http://purl.uniprot.org/core/author | "Haegebarth A."xsd:string |
| http://purl.uniprot.org/citations/23260145 | http://purl.uniprot.org/core/author | "Cuppen E."xsd:string |
| http://purl.uniprot.org/citations/23260145 | http://purl.uniprot.org/core/author | "Clevers H."xsd:string |
| http://purl.uniprot.org/citations/23260145 | http://purl.uniprot.org/core/author | "Chambon P."xsd:string |
| http://purl.uniprot.org/citations/23260145 | http://purl.uniprot.org/core/author | "van Es J.H."xsd:string |
| http://purl.uniprot.org/citations/23260145 | http://purl.uniprot.org/core/author | "Hatzis P."xsd:string |
| http://purl.uniprot.org/citations/23260145 | http://purl.uniprot.org/core/author | "Mokry M."xsd:string |
| http://purl.uniprot.org/citations/23260145 | http://purl.uniprot.org/core/author | "van den Born M."xsd:string |
| http://purl.uniprot.org/citations/23260145 | http://purl.uniprot.org/core/author | "Li V.S."xsd:string |
| http://purl.uniprot.org/citations/23260145 | http://purl.uniprot.org/core/author | "Boj S.F."xsd:string |
| http://purl.uniprot.org/citations/23260145 | http://purl.uniprot.org/core/author | "Voshol P."xsd:string |
| http://purl.uniprot.org/citations/23260145 | http://purl.uniprot.org/core/author | "Huch M."xsd:string |
| http://purl.uniprot.org/citations/23260145 | http://purl.uniprot.org/core/author | "Dor Y."xsd:string |
| http://purl.uniprot.org/citations/23260145 | http://purl.uniprot.org/core/author | "Fillat C."xsd:string |
| http://purl.uniprot.org/citations/23260145 | http://purl.uniprot.org/core/author | "Jose A."xsd:string |
| http://purl.uniprot.org/citations/23260145 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23260145 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/23260145 | http://purl.uniprot.org/core/pages | "1595-1607"xsd:string |
| http://purl.uniprot.org/citations/23260145 | http://purl.uniprot.org/core/title | "Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand."xsd:string |
| http://purl.uniprot.org/citations/23260145 | http://purl.uniprot.org/core/volume | "151"xsd:string |
| http://purl.uniprot.org/citations/23260145 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23260145 |
| http://purl.uniprot.org/citations/23260145 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23260145 |