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http://purl.uniprot.org/citations/23261508http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23261508http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23261508http://www.w3.org/2000/01/rdf-schema#comment"Antimicrobial peptides (AMPs) play important roles in innate immunity. One such AMP, epinecidin-1, exhibits antibacterial effects in zebrafish. In the current study, we aimed to identify the antimicrobial-associated proteins affected by epinecidin-1 treatment, and to unravel the underlying antimicrobial molecular mechanisms of epinecidin-1. We analyzed proteome changes in epinecidin-1-treated zebrafish using two-dimensional electrophoresis (2DE) coupled to mass spectrometry. Several differentially expressed proteins were identified, some of which were validated by real-time quantitative RT-PCR. The differentially expressed proteins were mapped onto Ingenuity Pathway Analysis canonical pathways, to construct a possible protein-protein interacting network regulated by epinecidin-1; this network suggested a potential role of epinecindin-1 in cytoskeletal assembly and organization. Our findings imply that epinecidin-1 may stabilize the cytoskeleton network in host cells, thereby promoting resistance to bacterial infection."xsd:string
http://purl.uniprot.org/citations/23261508http://purl.org/dc/terms/identifier"doi:10.1016/j.fsi.2012.11.032"xsd:string
http://purl.uniprot.org/citations/23261508http://purl.uniprot.org/core/author"Chen J.Y."xsd:string
http://purl.uniprot.org/citations/23261508http://purl.uniprot.org/core/author"Chen J.Y."xsd:string
http://purl.uniprot.org/citations/23261508http://purl.uniprot.org/core/author"Huang T.C."xsd:string
http://purl.uniprot.org/citations/23261508http://purl.uniprot.org/core/author"Huang T.C."xsd:string
http://purl.uniprot.org/citations/23261508http://purl.uniprot.org/core/date"2013"xsd:gYear
http://purl.uniprot.org/citations/23261508http://purl.uniprot.org/core/date"2013"xsd:gYear
http://purl.uniprot.org/citations/23261508http://purl.uniprot.org/core/name"Fish Shellfish Immunol."xsd:string
http://purl.uniprot.org/citations/23261508http://purl.uniprot.org/core/name"Fish Shellfish Immunol"xsd:string
http://purl.uniprot.org/citations/23261508http://purl.uniprot.org/core/pages"593-598"xsd:string
http://purl.uniprot.org/citations/23261508http://purl.uniprot.org/core/pages"593-598"xsd:string
http://purl.uniprot.org/citations/23261508http://purl.uniprot.org/core/title"Proteomic and functional analysis of zebrafish after administration of antimicrobial peptide epinecidin-1."xsd:string
http://purl.uniprot.org/citations/23261508http://purl.uniprot.org/core/title"Proteomic and functional analysis of zebrafish after administration of antimicrobial peptide epinecidin-1."xsd:string
http://purl.uniprot.org/citations/23261508http://purl.uniprot.org/core/volume"34"xsd:string
http://purl.uniprot.org/citations/23261508http://purl.uniprot.org/core/volume"34"xsd:string
http://purl.uniprot.org/citations/23261508http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/23261508
http://purl.uniprot.org/citations/23261508http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/23261508
http://purl.uniprot.org/citations/23261508http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/23261508
http://purl.uniprot.org/citations/23261508http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/23261508
http://purl.uniprot.org/uniprot/G8JL17http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/23261508
http://purl.uniprot.org/uniprot/#_G8JL17-citation-23261508http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23261508
http://purl.uniprot.org/uniprot/#_A3KPP4-mappedCitation-23261508http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23261508