| http://purl.uniprot.org/citations/23261989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23261989 | http://www.w3.org/2000/01/rdf-schema#comment | "Oxidative stress promotes endothelial cell senescence and endothelial dysfunction, important early steps in atherogenesis. To investigate potential antioxidant effects of IGF-1 we treated human aortic endothelial cells (hAECs) with 0-100ng/mL IGF-1 prior to exposure to native or oxidized low-density lipoprotein (oxLDL). IGF-1 dose- and time- dependently reduced basal- and oxLDL-induced ROS generation. IGF-1 did not alter superoxide dismutase or catalase activity but markedly increased activity of glutathione peroxidase (GPX), a crucial antioxidant enzyme, via a phosphoinositide-3 kinase dependent pathway. IGF-1 did not increase GPX1 mRNA levels but increased GPX1 protein levels by 2.6-fold at 24h, and altered selenocysteine-incorporation complex formation on GPX1 mRNA. Furthermore, IGF-1 blocked hydrogen peroxide induced premature cell senescence in hAECs. In conclusion, IGF-1 upregulates GPX1 expression in hAECs via a translational mechanism, which may play an important role in the ability of IGF-1 to reduce endothelial cell oxidative stress and premature senescence. Our findings have major implications for understanding vasculoprotective effects of IGF-1."xsd:string |
| http://purl.uniprot.org/citations/23261989 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbadis.2012.12.005"xsd:string |
| http://purl.uniprot.org/citations/23261989 | http://purl.uniprot.org/core/author | "Higashi Y."xsd:string |
| http://purl.uniprot.org/citations/23261989 | http://purl.uniprot.org/core/author | "Pandey A."xsd:string |
| http://purl.uniprot.org/citations/23261989 | http://purl.uniprot.org/core/author | "Goodwin B."xsd:string |
| http://purl.uniprot.org/citations/23261989 | http://purl.uniprot.org/core/author | "Delafontaine P."xsd:string |
| http://purl.uniprot.org/citations/23261989 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23261989 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/23261989 | http://purl.uniprot.org/core/pages | "391-399"xsd:string |
| http://purl.uniprot.org/citations/23261989 | http://purl.uniprot.org/core/title | "Insulin-like growth factor-1 regulates glutathione peroxidase expression and activity in vascular endothelial cells: Implications for atheroprotective actions of insulin-like growth factor-1."xsd:string |
| http://purl.uniprot.org/citations/23261989 | http://purl.uniprot.org/core/volume | "1832"xsd:string |
| http://purl.uniprot.org/citations/23261989 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23261989 |
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