| http://purl.uniprot.org/citations/23263626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23263626 | http://www.w3.org/2000/01/rdf-schema#comment | "Pulmonary arterial hypertension (PAH) is characterized by vascular remodeling associated with obliteration of pulmonary arterioles and formation of plexiform lesions composed of hyperproliferative endothelial and vascular smooth-muscle cells. Here we describe a microRNA (miRNA)-dependent association between apelin (APLN) and fibroblast growth factor 2 (FGF2) signaling in pulmonary artery endothelial cells (PAECs). APLN deficiency in these cells led to increased expression of FGF2 and its receptor FGFR1 as a consequence of decreased expression of miR-424 and miR-503, which directly target FGF2 and FGFR1. miR-424 and miR-503 were downregulated in PAH, exerted antiproliferative effects in PAECs and inhibited the capacity of PAEC-conditioned medium to induce the proliferation of pulmonary artery smooth-muscle cells. Reconstitution of miR-424 and miR-503 in vivo ameliorated pulmonary hypertension in experimental models. These studies identify an APLN-dependent miRNA-FGF signaling axis needed for the maintenance of pulmonary vascular homeostasis."xsd:string |
| http://purl.uniprot.org/citations/23263626 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm.3040"xsd:string |
| http://purl.uniprot.org/citations/23263626 | http://purl.uniprot.org/core/author | "Hu X."xsd:string |
| http://purl.uniprot.org/citations/23263626 | http://purl.uniprot.org/core/author | "Kim J."xsd:string |
| http://purl.uniprot.org/citations/23263626 | http://purl.uniprot.org/core/author | "Park H."xsd:string |
| http://purl.uniprot.org/citations/23263626 | http://purl.uniprot.org/core/author | "Kang Y."xsd:string |
| http://purl.uniprot.org/citations/23263626 | http://purl.uniprot.org/core/author | "Kojima Y."xsd:string |
| http://purl.uniprot.org/citations/23263626 | http://purl.uniprot.org/core/author | "Chun H.J."xsd:string |
| http://purl.uniprot.org/citations/23263626 | http://purl.uniprot.org/core/author | "Comhair S.A."xsd:string |
| http://purl.uniprot.org/citations/23263626 | http://purl.uniprot.org/core/author | "Erzurum S.C."xsd:string |
| http://purl.uniprot.org/citations/23263626 | http://purl.uniprot.org/core/author | "Aldred M.A."xsd:string |
| http://purl.uniprot.org/citations/23263626 | http://purl.uniprot.org/core/author | "Lighthouse J.K."xsd:string |
| http://purl.uniprot.org/citations/23263626 | http://purl.uniprot.org/core/author | "McLean D.L."xsd:string |
| http://purl.uniprot.org/citations/23263626 | http://purl.uniprot.org/core/author | "Greif D.M."xsd:string |
| http://purl.uniprot.org/citations/23263626 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23263626 | http://purl.uniprot.org/core/name | "Nat Med"xsd:string |
| http://purl.uniprot.org/citations/23263626 | http://purl.uniprot.org/core/pages | "74-82"xsd:string |
| http://purl.uniprot.org/citations/23263626 | http://purl.uniprot.org/core/title | "An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension."xsd:string |
| http://purl.uniprot.org/citations/23263626 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/23263626 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23263626 |
| http://purl.uniprot.org/citations/23263626 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23263626 |
| http://purl.uniprot.org/uniprot/Q9ULZ1#attribution-77B47AB649579EFEF052ADA8D60C1C0F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23263626 |
| http://purl.uniprot.org/uniprot/Q9ULZ1#attribution-C3D7E01F3D83143BA0FF7A8A30EA1CE9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23263626 |
| http://purl.uniprot.org/uniprot/Q9ULZ1#attribution-DA6A771607EC14CD33709F28CC362F11 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23263626 |