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| http://purl.uniprot.org/citations/23263986 | http://www.w3.org/2000/01/rdf-schema#comment | "Eukaryotic translation initiation factor 4F (eIF4F), comprising the cap-binding protein eIF4E, the helicase eIF4A, and the central scaffold eIF4G, is a convergence node for a complex signaling network that controls protein synthesis. Together with eIF3 and eIF4A/4B, eIF4G recruits ribosomal subunits to mRNAs and facilitates 5' untranslated region unwinding. Mammalian eIF4G contains three HEAT domains and unstructured regions involved in protein-protein interactions. Despite detailed eIF4G structure data, the mechanisms controlling initiation scaffold formation remain obscure. We found a new, highly regulated eIF4B/-3 binding site within the HEAT-1/-2 interdomain linker, harboring two phosphorylation sites that we identified as substrates for Erk1/2 and casein kinase 2. Phorbol ester-induced sequential phosphorylation of both sites detached HEAT-2 from the complex with eIF4A/-4B/-3 and stimulated the association of HEAT-3 with the mitogen-activated protein kinase signal integrating kinase Mnk1. Our results provide a mechanistic link between intracellular signal transduction and dynamic initiation complex formation coordinated by flexible eIF4G structure."xsd:string |
| http://purl.uniprot.org/citations/23263986 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01441-12"xsd:string |
| http://purl.uniprot.org/citations/23263986 | http://purl.uniprot.org/core/author | "Dobrikova E.Y."xsd:string |
| http://purl.uniprot.org/citations/23263986 | http://purl.uniprot.org/core/author | "Gromeier M."xsd:string |
| http://purl.uniprot.org/citations/23263986 | http://purl.uniprot.org/core/author | "Dobrikov M.I."xsd:string |
| http://purl.uniprot.org/citations/23263986 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23263986 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/23263986 | http://purl.uniprot.org/core/pages | "937-946"xsd:string |
| http://purl.uniprot.org/citations/23263986 | http://purl.uniprot.org/core/title | "Dynamic regulation of the translation initiation helicase complex by mitogenic signal transduction to eukaryotic translation initiation factor 4G."xsd:string |
| http://purl.uniprot.org/citations/23263986 | http://purl.uniprot.org/core/volume | "33"xsd:string |
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