| http://purl.uniprot.org/citations/23264733 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23264733 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23264733 | http://www.w3.org/2000/01/rdf-schema#comment | "Large cytoplasmic ribonucleoprotein germ granule complexes are a common feature in germ cells. In C. elegans these are called P granules and for much of the life-cycle they associate with nuclear pore complexes in germ cells. P granules are rich in proteins that function in diverse RNA pathways. Here we report that the C. elegans homolog of the eIF4E-transporter IFET-1 is required for oogenesis but not spermatogenesis. We show that IFET-1 is required for translational repression of several maternal mRNAs in the distal gonad and functions in conjunction with the broad-scale translational regulators CGH-1, CAR-1 and PATR-1 to regulate germ cell sex determination. Furthermore we have found that IFET-1 localizes to P granules throughout the gonad and in the germ cell lineage in the embryo. Interestingly, IFET-1 is required for the normal ultrastructure of P granules and for the localization of CGH-1 and CAR-1 to P granules. Our findings suggest that IFET-1 is a key translational regulator and is required for normal P granule formation."xsd:string |
| http://purl.uniprot.org/citations/23264733 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.119834"xsd:string |
| http://purl.uniprot.org/citations/23264733 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.119834"xsd:string |
| http://purl.uniprot.org/citations/23264733 | http://purl.uniprot.org/core/author | "Kim H.M."xsd:string |
| http://purl.uniprot.org/citations/23264733 | http://purl.uniprot.org/core/author | "Kim H.M."xsd:string |
| http://purl.uniprot.org/citations/23264733 | http://purl.uniprot.org/core/author | "Traven A."xsd:string |
| http://purl.uniprot.org/citations/23264733 | http://purl.uniprot.org/core/author | "Traven A."xsd:string |
| http://purl.uniprot.org/citations/23264733 | http://purl.uniprot.org/core/author | "Beilharz T.H."xsd:string |
| http://purl.uniprot.org/citations/23264733 | http://purl.uniprot.org/core/author | "Beilharz T.H."xsd:string |
| http://purl.uniprot.org/citations/23264733 | http://purl.uniprot.org/core/author | "Colaiacovo M.P."xsd:string |
| http://purl.uniprot.org/citations/23264733 | http://purl.uniprot.org/core/author | "Colaiacovo M.P."xsd:string |
| http://purl.uniprot.org/citations/23264733 | http://purl.uniprot.org/core/author | "Boag P.R."xsd:string |
| http://purl.uniprot.org/citations/23264733 | http://purl.uniprot.org/core/author | "Boag P.R."xsd:string |
| http://purl.uniprot.org/citations/23264733 | http://purl.uniprot.org/core/author | "Low W.Y."xsd:string |
| http://purl.uniprot.org/citations/23264733 | http://purl.uniprot.org/core/author | "Low W.Y."xsd:string |
| http://purl.uniprot.org/citations/23264733 | http://purl.uniprot.org/core/author | "Patterson J.R."xsd:string |
| http://purl.uniprot.org/citations/23264733 | http://purl.uniprot.org/core/author | "Patterson J.R."xsd:string |
| http://purl.uniprot.org/citations/23264733 | http://purl.uniprot.org/core/author | "Schisa J.A."xsd:string |
| http://purl.uniprot.org/citations/23264733 | http://purl.uniprot.org/core/author | "Schisa J.A."xsd:string |
| http://purl.uniprot.org/citations/23264733 | http://purl.uniprot.org/core/author | "Sengupta M.S."xsd:string |
| http://purl.uniprot.org/citations/23264733 | http://purl.uniprot.org/core/author | "Sengupta M.S."xsd:string |
| http://purl.uniprot.org/citations/23264733 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23264733 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |