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| http://purl.uniprot.org/citations/23267104 | http://www.w3.org/2000/01/rdf-schema#comment | "Despite the enormous proliferation of bacterial genome data, surprisingly persistent collections of bacterial proteins have resisted functional annotation. In a typical genome, roughly 30% of genes have no assigned function. Many of these proteins are conserved across a large number of bacterial genomes. To assign a putative function to these conserved proteins of unknown function, we created a physical interaction map by measuring biophysical interaction of these proteins. Binary protein--protein interactions in the model organism Streptococcus pneumoniae (TIGR4) are measured with a microfluidic high-throughput assay technology. In some cases, informatic analysis was used to restrict the space of potential binding partners. In other cases, we performed in vitro proteome-wide interaction screens. We were able to assign putative functions to 50 conserved proteins of unknown function that we studied with this approach."xsd:string |
| http://purl.uniprot.org/citations/23267104 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1210634110"xsd:string |
| http://purl.uniprot.org/citations/23267104 | http://purl.uniprot.org/core/author | "Meier M."xsd:string |
| http://purl.uniprot.org/citations/23267104 | http://purl.uniprot.org/core/author | "Quake S.R."xsd:string |
| http://purl.uniprot.org/citations/23267104 | http://purl.uniprot.org/core/author | "Sit R.V."xsd:string |
| http://purl.uniprot.org/citations/23267104 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23267104 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/23267104 | http://purl.uniprot.org/core/pages | "477-482"xsd:string |
| http://purl.uniprot.org/citations/23267104 | http://purl.uniprot.org/core/title | "Proteome-wide protein interaction measurements of bacterial proteins of unknown function."xsd:string |
| http://purl.uniprot.org/citations/23267104 | http://purl.uniprot.org/core/volume | "110"xsd:string |
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