| http://purl.uniprot.org/citations/23270756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23270756 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent reports suggest that the adult epicardium is a source of cardiac progenitor cells having the ability to undergo epithelial-to-mesenchymal transition (EMT) and predominantly differentiate into myofibroblasts, thereby contributing to fibrosis of the stressed myocardium. Islet-1 (Isl1) is a widely applied marker of progenitor cells, including the epicardial mesothelial cells (EMCs). However, little is known of the general biological function of Islet-1, let alone its role in EMT of EMCs. Using rat-derived adult EMC cultures we therefore investigated the role of Isl1 expression in both non-stimulated EMCs and during TGF-β-induced EMT. We found that Isl1 had a dual role by promoting mesenchymal features in non-stimulated EMCs, while a loss of Isl1 associated with EMT acted as a negative modulator of EMT progression as assessed on phenotype. We furthermore found that the loss of Isl1 expression during EMT was, in addition to transcriptional regulation by β-catenin, mediated through direct targeting by microRNA-31 (miR-31). Through manipulations of miR-31 bioactivity in EMCs, we thus report that miR-31 is a negative modulator of cardiac fibrogenic EMT, primarily via targeting Isl1. Our data show that Isl1 is a key regulatory molecule in adult cardiac EMT."xsd:string |
| http://purl.uniprot.org/citations/23270756 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2012.12.019"xsd:string |
| http://purl.uniprot.org/citations/23270756 | http://purl.uniprot.org/core/author | "Schneider M."xsd:string |
| http://purl.uniprot.org/citations/23270756 | http://purl.uniprot.org/core/author | "Sheikh S.P."xsd:string |
| http://purl.uniprot.org/citations/23270756 | http://purl.uniprot.org/core/author | "Nielsen S.B."xsd:string |
| http://purl.uniprot.org/citations/23270756 | http://purl.uniprot.org/core/author | "Nossent A.Y."xsd:string |
| http://purl.uniprot.org/citations/23270756 | http://purl.uniprot.org/core/author | "Andersen D.C."xsd:string |
| http://purl.uniprot.org/citations/23270756 | http://purl.uniprot.org/core/author | "Bronnum H."xsd:string |
| http://purl.uniprot.org/citations/23270756 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23270756 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/23270756 | http://purl.uniprot.org/core/pages | "424-435"xsd:string |
| http://purl.uniprot.org/citations/23270756 | http://purl.uniprot.org/core/title | "Islet-1 is a dual regulator of fibrogenic epithelial-to-mesenchymal transition in epicardial mesothelial cells."xsd:string |
| http://purl.uniprot.org/citations/23270756 | http://purl.uniprot.org/core/volume | "319"xsd:string |
| http://purl.uniprot.org/citations/23270756 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23270756 |
| http://purl.uniprot.org/citations/23270756 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23270756 |
| http://purl.uniprot.org/uniprot/Q9WU82#attribution-E7B9D647799CF1E2ABBA235247556138 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23270756 |
| http://purl.uniprot.org/uniprot/P61374#attribution-509BD9A5E0439E306A41A0D3C0120208 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23270756 |
| http://purl.uniprot.org/uniprot/P61374#attribution-666B5BE46F00AD58C1C895FB3BF5551E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23270756 |
| http://purl.uniprot.org/uniprot/P61374#attribution-E7B9D647799CF1E2ABBA235247556138 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23270756 |
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| http://purl.uniprot.org/uniprot/#_A0A8I5ZYX5-mappedCitation-23270756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23270756 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JT93-mappedCitation-23270756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23270756 |