http://purl.uniprot.org/citations/23272845 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/23272845 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundTransforming growth factor-β activated kinase-1 (TAK1) is a serine/threonine kinase in the mitogen-activated protein kinase kinase family. Previous studies have reported the role of TAK1 in cancer occurrence and progression; however, its role and clinical significance in esophageal squamous cell carcinoma (ESCC) has not been elucidated. We investigated the correlation of TAK1 expression and clinical outcome in T3N1-3M0 surgically resected ESCCs.MethodsTissue microarrays constructed of 234 surgically resected T3N1-3M0 ESCC primary tumors were used for TAK1 evaluation by immunohistochemistry. The clinical and prognostic significance of TAK1 expression was analyzed statistically.ResultsPositive expression of TAK1 was observed in 38.5% (90 of 234). The expression level of TAK1 in ESCCs at stage N2-3 was significantly higher than the expression level in those at stage N1 (p = 0.041). Patients with negative TAK1 expression demonstrated better overall survival than those with positive expression (median, 22.7 vs 17.4 months; p = 0.023). Multivariate analysis showed that TAK1 expression was an independent prognostic factor in ESCC (relative risk, 1.429; p = 0.021).ConclusionsTAK1 expression correlates with lymph node metastasis and is a negative, independent prognostic factor in resected T3N1-3M0 ESCCs."xsd:string |
http://purl.uniprot.org/citations/23272845 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.athoracsur.2012.09.050"xsd:string |
http://purl.uniprot.org/citations/23272845 | http://purl.uniprot.org/core/author | "Hu Y."xsd:string |
http://purl.uniprot.org/citations/23272845 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
http://purl.uniprot.org/citations/23272845 | http://purl.uniprot.org/core/author | "Wen J."xsd:string |
http://purl.uniprot.org/citations/23272845 | http://purl.uniprot.org/core/author | "Zhang S.S."xsd:string |
http://purl.uniprot.org/citations/23272845 | http://purl.uniprot.org/core/author | "Fu J.H."xsd:string |
http://purl.uniprot.org/citations/23272845 | http://purl.uniprot.org/core/author | "Luo K.J."xsd:string |
http://purl.uniprot.org/citations/23272845 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
http://purl.uniprot.org/citations/23272845 | http://purl.uniprot.org/core/name | "Ann Thorac Surg"xsd:string |
http://purl.uniprot.org/citations/23272845 | http://purl.uniprot.org/core/pages | "285-290"xsd:string |
http://purl.uniprot.org/citations/23272845 | http://purl.uniprot.org/core/title | "Positive transforming growth factor-beta activated kinase-1 expression has an unfavorable impact on survival in T3N1-3M0 esophageal squamous cell carcinomas."xsd:string |
http://purl.uniprot.org/citations/23272845 | http://purl.uniprot.org/core/volume | "95"xsd:string |
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