| http://purl.uniprot.org/citations/23273993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23273993 | http://www.w3.org/2000/01/rdf-schema#comment | "Cell-type plasticity within a tumor has recently been suggested to cause a bidirectional conversion between tumor-initiating stem cells and nonstem cells triggered by an inflammatory stroma. NF-κB represents a key transcription factor within the inflammatory tumor microenvironment. However, NF-κB's function in tumor-initiating cells has not been examined yet. Using a genetic model of intestinal epithelial cell (IEC)-restricted constitutive Wnt-activation, which comprises the most common event in the initiation of colon cancer, we demonstrate that NF-κB modulates Wnt signaling and show that IEC-specific ablation of RelA/p65 retards crypt stem cell expansion. In contrast, elevated NF-κB signaling enhances Wnt activation and induces dedifferentiation of nonstem cells that acquire tumor-initiating capacity. Thus, our data support the concept of bidirectional conversion and highlight the importance of inflammatory signaling for dedifferentiation and generation of tumor-initiating cells in vivo."xsd:string |
| http://purl.uniprot.org/citations/23273993 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2012.12.012"xsd:string |
| http://purl.uniprot.org/citations/23273993 | http://purl.uniprot.org/core/author | "Schmid R."xsd:string |
| http://purl.uniprot.org/citations/23273993 | http://purl.uniprot.org/core/author | "Barker N."xsd:string |
| http://purl.uniprot.org/citations/23273993 | http://purl.uniprot.org/core/author | "Kirchner T."xsd:string |
| http://purl.uniprot.org/citations/23273993 | http://purl.uniprot.org/core/author | "Clevers H."xsd:string |
| http://purl.uniprot.org/citations/23273993 | http://purl.uniprot.org/core/author | "Lang R."xsd:string |
| http://purl.uniprot.org/citations/23273993 | http://purl.uniprot.org/core/author | "Taketo M.M."xsd:string |
| http://purl.uniprot.org/citations/23273993 | http://purl.uniprot.org/core/author | "Moreaux G."xsd:string |
| http://purl.uniprot.org/citations/23273993 | http://purl.uniprot.org/core/author | "Gerhard M."xsd:string |
| http://purl.uniprot.org/citations/23273993 | http://purl.uniprot.org/core/author | "Heijmans J."xsd:string |
| http://purl.uniprot.org/citations/23273993 | http://purl.uniprot.org/core/author | "van den Brink G.R."xsd:string |
| http://purl.uniprot.org/citations/23273993 | http://purl.uniprot.org/core/author | "Neumann J."xsd:string |
| http://purl.uniprot.org/citations/23273993 | http://purl.uniprot.org/core/author | "Sansom O.J."xsd:string |
| http://purl.uniprot.org/citations/23273993 | http://purl.uniprot.org/core/author | "Rupec R.A."xsd:string |
| http://purl.uniprot.org/citations/23273993 | http://purl.uniprot.org/core/author | "Greten F.R."xsd:string |
| http://purl.uniprot.org/citations/23273993 | http://purl.uniprot.org/core/author | "Ziegler P.K."xsd:string |
| http://purl.uniprot.org/citations/23273993 | http://purl.uniprot.org/core/author | "Cammareri P."xsd:string |
| http://purl.uniprot.org/citations/23273993 | http://purl.uniprot.org/core/author | "Fingerle A.A."xsd:string |
| http://purl.uniprot.org/citations/23273993 | http://purl.uniprot.org/core/author | "Arkan M.C."xsd:string |
| http://purl.uniprot.org/citations/23273993 | http://purl.uniprot.org/core/author | "Goktuna S.I."xsd:string |
| http://purl.uniprot.org/citations/23273993 | http://purl.uniprot.org/core/author | "Nebelsiek T."xsd:string |
| http://purl.uniprot.org/citations/23273993 | http://purl.uniprot.org/core/author | "Canli O."xsd:string |
| http://purl.uniprot.org/citations/23273993 | http://purl.uniprot.org/core/author | "Schwitalla S."xsd:string |