| http://purl.uniprot.org/citations/23274911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23274911 | http://www.w3.org/2000/01/rdf-schema#comment | "N-RAS is one member of a family of oncoproteins that are commonly mutated in cancer. Activating mutations in NRAS occur in a subset of colorectal cancers, but little is known about how the mutant protein contributes to the onset and progression of the disease. Using genetically engineered mice, we find that mutant N-RAS strongly promotes tumorigenesis in the context of inflammation. The protumorigenic nature of mutant N-RAS is related to its antiapoptotic function, which is mediated by activation of a noncanonical mitogen-activated protein kinase pathway that signals through STAT3. As a result, inhibition of MAP-ERK kinase selectively induces apoptosis in autochthonous colonic tumors expressing mutant N-RAS. The translational significance of this finding is highlighted by our observation that NRAS mutation correlates with a less favorable clinical outcome for patients with colorectal cancer. These data show for the first time the important role that N-RAS plays in colorectal cancer."xsd:string |
| http://purl.uniprot.org/citations/23274911 | http://purl.org/dc/terms/identifier | "doi:10.1158/2159-8290.cd-12-0198"xsd:string |
| http://purl.uniprot.org/citations/23274911 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/23274911 | http://purl.uniprot.org/core/author | "Peng S."xsd:string |
| http://purl.uniprot.org/citations/23274911 | http://purl.uniprot.org/core/author | "Der C.J."xsd:string |
| http://purl.uniprot.org/citations/23274911 | http://purl.uniprot.org/core/author | "Philips M."xsd:string |
| http://purl.uniprot.org/citations/23274911 | http://purl.uniprot.org/core/author | "Haigis K.M."xsd:string |
| http://purl.uniprot.org/citations/23274911 | http://purl.uniprot.org/core/author | "Chu G.C."xsd:string |
| http://purl.uniprot.org/citations/23274911 | http://purl.uniprot.org/core/author | "Velho S."xsd:string |
| http://purl.uniprot.org/citations/23274911 | http://purl.uniprot.org/core/author | "Bugni J.M."xsd:string |
| http://purl.uniprot.org/citations/23274911 | http://purl.uniprot.org/core/author | "Solit D.B."xsd:string |
| http://purl.uniprot.org/citations/23274911 | http://purl.uniprot.org/core/author | "Vakiani E."xsd:string |
| http://purl.uniprot.org/citations/23274911 | http://purl.uniprot.org/core/author | "Bass A.J."xsd:string |
| http://purl.uniprot.org/citations/23274911 | http://purl.uniprot.org/core/author | "Gierut J."xsd:string |
| http://purl.uniprot.org/citations/23274911 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23274911 | http://purl.uniprot.org/core/name | "Cancer Discov"xsd:string |
| http://purl.uniprot.org/citations/23274911 | http://purl.uniprot.org/core/pages | "294-307"xsd:string |
| http://purl.uniprot.org/citations/23274911 | http://purl.uniprot.org/core/title | "Mutant N-RAS protects colorectal cancer cells from stress-induced apoptosis and contributes to cancer development and progression."xsd:string |
| http://purl.uniprot.org/citations/23274911 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/23274911 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23274911 |
| http://purl.uniprot.org/citations/23274911 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23274911 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JE25-mappedCitation-23274911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23274911 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGM2-mappedCitation-23274911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23274911 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGP4-mappedCitation-23274911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23274911 |