| http://purl.uniprot.org/citations/23275439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23275439 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein kinase C (PKC)-potentiated inhibitory protein of 17 kDa (CPI-17) inhibits myosin light chain phosphatase, altering the levels of myosin light chain phosphorylation and Ca(2+) sensitivity in smooth muscle. In this study, we characterized the CPI-17 promoter and identified binding sites for GATA-6 and nuclear factor kappa B (NF-κB). GATA-6 and NF-κB upregulated CPI-17 expression in cultured human and mouse bladder smooth muscle (BSM) cells in an additive manner. CPI-17 expression was decreased upon GATA-6 silencing in cultured BSM cells and in BSM from NF-κB knockout (KO) mice. Moreover, force maintenance by BSM strips from KO mice was decreased compared with the force maintenance of BSM strips from wild-type mice. GATA-6 and NF-κB overexpression was associated with CPI-17 overexpression in BSM from men with benign prostatic hyperplasia (BPH)-induced bladder hypertrophy and in a mouse model of bladder outlet obstruction. Thus, aberrant expression of NF-κB and GATA-6 deregulates CPI-17 expression and the contractile function of smooth muscle. Our data provide insight into how GATA-6 and NF-κB mediate CPI-17 transcription, PKC-mediated signaling, and BSM remodeling associated with lower urinary tract symptoms in patients with BPH."xsd:string |
| http://purl.uniprot.org/citations/23275439 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00626-12"xsd:string |
| http://purl.uniprot.org/citations/23275439 | http://purl.uniprot.org/core/author | "Gomes C.M."xsd:string |
| http://purl.uniprot.org/citations/23275439 | http://purl.uniprot.org/core/author | "Malkowicz B."xsd:string |
| http://purl.uniprot.org/citations/23275439 | http://purl.uniprot.org/core/author | "Boopathi E."xsd:string |
| http://purl.uniprot.org/citations/23275439 | http://purl.uniprot.org/core/author | "Chacko S."xsd:string |
| http://purl.uniprot.org/citations/23275439 | http://purl.uniprot.org/core/author | "Wein A.J."xsd:string |
| http://purl.uniprot.org/citations/23275439 | http://purl.uniprot.org/core/author | "Liou H.C."xsd:string |
| http://purl.uniprot.org/citations/23275439 | http://purl.uniprot.org/core/author | "Zderic S.A."xsd:string |
| http://purl.uniprot.org/citations/23275439 | http://purl.uniprot.org/core/author | "Hypolite J.A."xsd:string |
| http://purl.uniprot.org/citations/23275439 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23275439 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/23275439 | http://purl.uniprot.org/core/pages | "1085-1102"xsd:string |
| http://purl.uniprot.org/citations/23275439 | http://purl.uniprot.org/core/title | "GATA-6 and NF-kappaB activate CPI-17 gene transcription and regulate Ca2+ sensitization of smooth muscle contraction."xsd:string |
| http://purl.uniprot.org/citations/23275439 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/23275439 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23275439 |
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