| http://purl.uniprot.org/citations/23276384 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23276384 | http://www.w3.org/2000/01/rdf-schema#comment | "Alzheimer's disease (AD) involves progressive accumulation of amyloid β-peptide (Aβ) and neurofibrillary pathologies, and glucose hypometabolism in brain regions critical for memory. The 3xTgAD mouse model was used to test the hypothesis that a ketone ester-based diet can ameliorate AD pathogenesis. Beginning at a presymptomatic age, 2 groups of male 3xTgAD mice were fed a diet containing a physiological enantiomeric precursor of ketone bodies (KET) or an isocaloric carbohydrate diet. The results of behavioral tests performed at 4 and 7 months after diet initiation revealed that KET-fed mice exhibited significantly less anxiety in 2 different tests. 3xTgAD mice on the KET diet also exhibited significant, albeit relatively subtle, improvements in performance on learning and memory tests. Immunohistochemical analyses revealed that KET-fed mice exhibited decreased Aβ deposition in the subiculum, CA1 and CA3 regions of the hippocampus, and the amygdala. KET-fed mice exhibited reduced levels of hyperphosphorylated tau deposition in the same regions of the hippocampus, amygdala, and cortex. Thus, a novel ketone ester can ameliorate proteopathic and behavioral deficits in a mouse AD model."xsd:string |
| http://purl.uniprot.org/citations/23276384 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neurobiolaging.2012.11.023"xsd:string |
| http://purl.uniprot.org/citations/23276384 | http://purl.uniprot.org/core/author | "Clarke K."xsd:string |
| http://purl.uniprot.org/citations/23276384 | http://purl.uniprot.org/core/author | "Lee J.H."xsd:string |
| http://purl.uniprot.org/citations/23276384 | http://purl.uniprot.org/core/author | "Mattson M.P."xsd:string |
| http://purl.uniprot.org/citations/23276384 | http://purl.uniprot.org/core/author | "Wan R."xsd:string |
| http://purl.uniprot.org/citations/23276384 | http://purl.uniprot.org/core/author | "King M.T."xsd:string |
| http://purl.uniprot.org/citations/23276384 | http://purl.uniprot.org/core/author | "Mughal M.R."xsd:string |
| http://purl.uniprot.org/citations/23276384 | http://purl.uniprot.org/core/author | "Bergman C."xsd:string |
| http://purl.uniprot.org/citations/23276384 | http://purl.uniprot.org/core/author | "Veech R.L."xsd:string |
| http://purl.uniprot.org/citations/23276384 | http://purl.uniprot.org/core/author | "Kashiwaya Y."xsd:string |
| http://purl.uniprot.org/citations/23276384 | http://purl.uniprot.org/core/author | "Okun E."xsd:string |
| http://purl.uniprot.org/citations/23276384 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23276384 | http://purl.uniprot.org/core/name | "Neurobiol Aging"xsd:string |
| http://purl.uniprot.org/citations/23276384 | http://purl.uniprot.org/core/pages | "1530-1539"xsd:string |
| http://purl.uniprot.org/citations/23276384 | http://purl.uniprot.org/core/title | "A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/23276384 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/23276384 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23276384 |
| http://purl.uniprot.org/citations/23276384 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23276384 |
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| http://purl.uniprot.org/uniprot/#_B3KTM0-mappedCitation-23276384 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23276384 |
| http://purl.uniprot.org/uniprot/#_B4DSB3-mappedCitation-23276384 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23276384 |
| http://purl.uniprot.org/uniprot/#_B7U472-mappedCitation-23276384 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23276384 |
| http://purl.uniprot.org/uniprot/#_P10636-mappedCitation-23276384 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23276384 |