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| http://purl.uniprot.org/citations/23277196 | http://www.w3.org/2000/01/rdf-schema#comment | "In this article, we are reviewing the molecular mechanisms that lead to kinase inhibitor resistance. As the oncogenic BCR-ABL kinase is the target of the first approved small-molecule kinase inhibitor imatinib, we will first focus on the structural and mechanistic basis for imatinib resistance. We will then show ways how next generations of BCR-ABL inhibitors and alternative targeting strategies have helped to offer effective treatment options for imatinib-resistant patients. Based on these insights, we discuss commonalities and further mechanisms that lead to resistance to other kinase inhibitors in solid tumors. This article is part of a Special Issue entitled: Inhibitors of Protein Kinases (2012)."xsd:string |
| http://purl.uniprot.org/citations/23277196 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbapap.2012.12.009"xsd:string |
| http://purl.uniprot.org/citations/23277196 | http://purl.uniprot.org/core/author | "Hantschel O."xsd:string |
| http://purl.uniprot.org/citations/23277196 | http://purl.uniprot.org/core/author | "Gencer E.B."xsd:string |
| http://purl.uniprot.org/citations/23277196 | http://purl.uniprot.org/core/author | "Kuzyk O."xsd:string |
| http://purl.uniprot.org/citations/23277196 | http://purl.uniprot.org/core/author | "Lamontanara A.J."xsd:string |
| http://purl.uniprot.org/citations/23277196 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23277196 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/23277196 | http://purl.uniprot.org/core/pages | "1449-1459"xsd:string |
| http://purl.uniprot.org/citations/23277196 | http://purl.uniprot.org/core/title | "Mechanisms of resistance to BCR-ABL and other kinase inhibitors."xsd:string |
| http://purl.uniprot.org/citations/23277196 | http://purl.uniprot.org/core/volume | "1834"xsd:string |
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