| http://purl.uniprot.org/citations/23277542 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23277542 | http://www.w3.org/2000/01/rdf-schema#comment | "The oncogenic transcription factor c-Myc causes transformation and tumorigenesis, but it can also induce apoptotic cell death. Although tumor suppressors are necessary for c-Myc to induce apoptosis, the pathways and mechanisms are unclear. To further understand how c-Myc switches from an oncogenic protein to an apoptotic protein, we examined the mechanism of p53-independent c-Myc-induced apoptosis. We show that the tumor suppressor protein ARF mediates this switch by inhibiting ubiquitylation of the c-Myc transcriptional domain (TD). Whereas TD ubiquitylation is critical for c-Myc canonical transcriptional activity and transformation, inhibition of ubiquitylation leads to the induction of the noncanonical c-Myc target gene, Egr1, which is essential for efficient c-Myc-induced p53-independent apoptosis. ARF inhibits the interaction of c-Myc with the E3 ubiquitin ligase Skp2. Overexpression of Skp2, which occurs in many human tumors, inhibits the recruitment of ARF to the Egr1 promoter, leading to inhibition of c-Myc-induced apoptosis. Therapeutic strategies could be developed to activate this intrinsic apoptotic activity of c-Myc to inhibit tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/23277542 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1208334110"xsd:string |
| http://purl.uniprot.org/citations/23277542 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/23277542 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/23277542 | http://purl.uniprot.org/core/author | "Gregory M.A."xsd:string |
| http://purl.uniprot.org/citations/23277542 | http://purl.uniprot.org/core/author | "Hann S.R."xsd:string |
| http://purl.uniprot.org/citations/23277542 | http://purl.uniprot.org/core/author | "Boone D.N."xsd:string |
| http://purl.uniprot.org/citations/23277542 | http://purl.uniprot.org/core/author | "Spears E."xsd:string |
| http://purl.uniprot.org/citations/23277542 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23277542 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/23277542 | http://purl.uniprot.org/core/pages | "978-983"xsd:string |
| http://purl.uniprot.org/citations/23277542 | http://purl.uniprot.org/core/title | "Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity."xsd:string |
| http://purl.uniprot.org/citations/23277542 | http://purl.uniprot.org/core/volume | "110"xsd:string |
| http://purl.uniprot.org/citations/23277542 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23277542 |
| http://purl.uniprot.org/citations/23277542 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23277542 |
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