| http://purl.uniprot.org/citations/23289765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23289765 | http://www.w3.org/2000/01/rdf-schema#comment | "The ability of T cells to activate antimicrobial pathways in infected macrophages is essential to host defence against many intracellular pathogens. Here, we compared the ability of two T-cell-mediated mechanisms to trigger antimicrobial responses against Mycobacterium tuberculosis in humans, CD40 activation and the release of interferon-γ (IFN-γ). Given that IFN-γ activates a vitamin D-dependent antimicrobial response, we focused on induction of the key components of this pathway. We show that activation of human monocytes via CD40 ligand (CD40L) and IFN-γ, alone, and in combination, induces the CYP27b1-hydroxylase, responsible for the conversion of 25-hydroxyvitamin D (25D) to the bioactive 1,25-dihydroxyvitamin D (1,25D), and the vitamin D receptor (VDR). The activation of the vitamin D pathway by CD40L and IFN-γ results in up-regulated expression of the antimicrobial peptides, cathelicidin and DEFB4, as well as induction of autophagy. Finally, activation of monocytes via CD40L and IFN-γ results in an antimicrobial activity against intracellular M. tuberculosis. Our data suggest that at least two parallel T-cell-mediated mechanisms, CD40L and IFN-γ, activate the vitamin D-dependent antimicrobial pathway and trigger antimicrobial activity against intracellular M. tuberculosis, thereby contributing to human host defence against intracellular infection."xsd:string |
| http://purl.uniprot.org/citations/23289765 | http://purl.org/dc/terms/identifier | "doi:10.1111/imm.12062"xsd:string |
| http://purl.uniprot.org/citations/23289765 | http://purl.uniprot.org/core/author | "Krutzik S.R."xsd:string |
| http://purl.uniprot.org/citations/23289765 | http://purl.uniprot.org/core/author | "Modlin R.L."xsd:string |
| http://purl.uniprot.org/citations/23289765 | http://purl.uniprot.org/core/author | "Sommer A."xsd:string |
| http://purl.uniprot.org/citations/23289765 | http://purl.uniprot.org/core/author | "Fabri M."xsd:string |
| http://purl.uniprot.org/citations/23289765 | http://purl.uniprot.org/core/author | "Stenger S."xsd:string |
| http://purl.uniprot.org/citations/23289765 | http://purl.uniprot.org/core/author | "Liu P.T."xsd:string |
| http://purl.uniprot.org/citations/23289765 | http://purl.uniprot.org/core/author | "Klug-Micu G.M."xsd:string |
| http://purl.uniprot.org/citations/23289765 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23289765 | http://purl.uniprot.org/core/name | "Immunology"xsd:string |
| http://purl.uniprot.org/citations/23289765 | http://purl.uniprot.org/core/pages | "121-128"xsd:string |
| http://purl.uniprot.org/citations/23289765 | http://purl.uniprot.org/core/title | "CD40 ligand and interferon-gamma induce an antimicrobial response against Mycobacterium tuberculosis in human monocytes."xsd:string |
| http://purl.uniprot.org/citations/23289765 | http://purl.uniprot.org/core/volume | "139"xsd:string |
| http://purl.uniprot.org/citations/23289765 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23289765 |
| http://purl.uniprot.org/citations/23289765 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23289765 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GUN6-mappedCitation-23289765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23289765 |
| http://purl.uniprot.org/uniprot/#_A8YQE4-mappedCitation-23289765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23289765 |
| http://purl.uniprot.org/uniprot/#_A1Z2M2-mappedCitation-23289765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23289765 |
| http://purl.uniprot.org/uniprot/#_C1L3E0-mappedCitation-23289765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23289765 |
| http://purl.uniprot.org/uniprot/#_Q14609-mappedCitation-23289765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23289765 |
| http://purl.uniprot.org/uniprot/#_Q14610-mappedCitation-23289765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23289765 |
| http://purl.uniprot.org/uniprot/#_Q14611-mappedCitation-23289765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23289765 |
| http://purl.uniprot.org/uniprot/#_Q14612-mappedCitation-23289765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23289765 |