| http://purl.uniprot.org/citations/23292142 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23292142 | http://www.w3.org/2000/01/rdf-schema#comment | "Histone deacetylase 3 (HDAC3) is an epigenome-modifying enzyme that is required for normal mouse development and tissue-specific functions. In vitro, HDAC3 protein itself has minimal enzyme activity but gains its histone-deacetylation function from stable association with the conserved deacetylase-activating domain (DAD) contained in nuclear receptor co-repressors NCOR1 and SMRT. Here we show that HDAC3 enzyme activity is undetectable in mice bearing point mutations in the DAD of both NCOR1 and SMRT (NS-DADm), despite having normal levels of HDAC3 protein. Local histone acetylation is increased, and genomic HDAC3 recruitment is reduced though not abrogated. Notably, NS-DADm mice are born and live to adulthood, whereas genetic deletion of HDAC3 is embryonic lethal. These findings demonstrate that nuclear receptor co-repressors are required for HDAC3 enzyme activity in vivo and suggest that a deacetylase-independent function of HDAC3 may be required for life."xsd:string |
| http://purl.uniprot.org/citations/23292142 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.2476"xsd:string |
| http://purl.uniprot.org/citations/23292142 | http://purl.uniprot.org/core/author | "Sun Z."xsd:string |
| http://purl.uniprot.org/citations/23292142 | http://purl.uniprot.org/core/author | "Lazar M.A."xsd:string |
| http://purl.uniprot.org/citations/23292142 | http://purl.uniprot.org/core/author | "Lim H.W."xsd:string |
| http://purl.uniprot.org/citations/23292142 | http://purl.uniprot.org/core/author | "Won K.J."xsd:string |
| http://purl.uniprot.org/citations/23292142 | http://purl.uniprot.org/core/author | "You S.H."xsd:string |
| http://purl.uniprot.org/citations/23292142 | http://purl.uniprot.org/core/author | "Broache M."xsd:string |
| http://purl.uniprot.org/citations/23292142 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23292142 | http://purl.uniprot.org/core/name | "Nat Struct Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/23292142 | http://purl.uniprot.org/core/pages | "182-187"xsd:string |
| http://purl.uniprot.org/citations/23292142 | http://purl.uniprot.org/core/title | "Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo."xsd:string |
| http://purl.uniprot.org/citations/23292142 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/23292142 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23292142 |
| http://purl.uniprot.org/citations/23292142 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23292142 |
| http://purl.uniprot.org/uniprot/#_E9Q9V3-mappedCitation-23292142 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23292142 |
| http://purl.uniprot.org/uniprot/#_E9Q9Y2-mappedCitation-23292142 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23292142 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JED1-mappedCitation-23292142 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23292142 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JEQ5-mappedCitation-23292142 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23292142 |
| http://purl.uniprot.org/uniprot/#_D3Z2J5-mappedCitation-23292142 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23292142 |
| http://purl.uniprot.org/uniprot/#_E0CYX5-mappedCitation-23292142 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23292142 |
| http://purl.uniprot.org/uniprot/#_E9Q701-mappedCitation-23292142 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23292142 |
| http://purl.uniprot.org/uniprot/#_A0A494B9Q7-mappedCitation-23292142 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23292142 |
| http://purl.uniprot.org/uniprot/#_F7C134-mappedCitation-23292142 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23292142 |