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http://purl.uniprot.org/citations/23295285http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23295285http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the association of the T allele of the single nucleotide polymorphism (SNP) rs7903146 of TCF7L2 with the occurrence of T2D in a sample of subjects followed up at the Brasilia University Hospital.

Subjects and methods

The SNP rs7903146 of TCF7L2 was genotyped by allele-specific PCR in 113 patients with known T2D and in 139 non-diabetic controls in Brasilia, Brazil.

Results

We found that the T allele of the SNP rs7903146 of TCF7L2 was significantly associated with T2D risk (odds ratio of 3.92 for genotype TT in the recessive genetic model, p = 0.004 and 1.5 for T allele, p = 0.032).

Conclusion

These results reinforce previous findings on the consistent association of this genetic factor and the risk of T2D in populations of diverse ethnic backgrounds."xsd:string
http://purl.uniprot.org/citations/23295285http://purl.org/dc/terms/identifier"doi:10.1590/s0004-27302012000800003"xsd:string
http://purl.uniprot.org/citations/23295285http://purl.uniprot.org/core/author"Azevedo M.F."xsd:string
http://purl.uniprot.org/citations/23295285http://purl.uniprot.org/core/author"Amato A.A."xsd:string
http://purl.uniprot.org/citations/23295285http://purl.uniprot.org/core/author"Barra G.B."xsd:string
http://purl.uniprot.org/citations/23295285http://purl.uniprot.org/core/author"Costa P.G."xsd:string
http://purl.uniprot.org/citations/23295285http://purl.uniprot.org/core/author"Dutra L.A."xsd:string
http://purl.uniprot.org/citations/23295285http://purl.uniprot.org/core/author"Cruz P.S."xsd:string
http://purl.uniprot.org/citations/23295285http://purl.uniprot.org/core/author"Watanabe S.C."xsd:string
http://purl.uniprot.org/citations/23295285http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/23295285http://purl.uniprot.org/core/name"Arq Bras Endocrinol Metabol"xsd:string
http://purl.uniprot.org/citations/23295285http://purl.uniprot.org/core/pages"479-484"xsd:string
http://purl.uniprot.org/citations/23295285http://purl.uniprot.org/core/title"Association of the rs7903146 single nucleotide polymorphism at the Transcription Factor 7-like 2 (TCF7L2) locus with type 2 diabetes in Brazilian subjects."xsd:string
http://purl.uniprot.org/citations/23295285http://purl.uniprot.org/core/volume"56"xsd:string
http://purl.uniprot.org/citations/23295285http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/23295285
http://purl.uniprot.org/citations/23295285http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/23295285
http://purl.uniprot.org/uniprot/#_A0A0D9SGH8-mappedCitation-23295285http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23295285
http://purl.uniprot.org/uniprot/#_A0A0A0MTL7-mappedCitation-23295285http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23295285
http://purl.uniprot.org/uniprot/#_E2GH26-mappedCitation-23295285http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23295285
http://purl.uniprot.org/uniprot/#_A0A994J711-mappedCitation-23295285http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23295285
http://purl.uniprot.org/uniprot/#_A0A2Z5HTM8-mappedCitation-23295285http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23295285
http://purl.uniprot.org/uniprot/#_A0A2Z5HTN9-mappedCitation-23295285http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23295285
http://purl.uniprot.org/uniprot/#_B4DJZ2-mappedCitation-23295285http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23295285
http://purl.uniprot.org/uniprot/#_B3KQC6-mappedCitation-23295285http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23295285
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